NELTENEXINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H20Br2N2O2S
Molecular Weight	488.237
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O[C@H]1CC[C@@H](CC1)NCC2=C(NC(=O)C3=CC=CS3)C(Br)=CC(Br)=C2

InChI

InChIKey=SSLHKNBKUBAHJY-HDJSIYSDSA-N

InChI=1S/C18H20Br2N2O2S/c19-12-8-11(10-21-13-3-5-14(23)6-4-13)17(15(20)9-12)22-18(24)16-2-1-7-25-16/h1-2,7-9,13-14,21,23H,3-6,10H2,(H,22,24)/t13-,14-

HIDE SMILES / InChI

Molecular Formula	C18H20Br2N2O2S
Molecular Weight	488.237
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/mesh/67095919 | https://www.ncbi.nlm.nih.gov/pubmed/11535970 | https://www.drugs.com/international/neltenexine.html

NELTENEXINE, an amide derivative of ambroxol and thiophenecarboxylic acid, is a mucolytic agent. It is an elastase inhibitor used in the treatment of human lung diseases.

Approval Year

PubMed

Title	Date	PubMed
Neltenexine tablets in smoking and non-smoking patients with COPD. A double-blind, randomised, controlled study versus placebo.	2001 Aug	11535971
Oral neltenexine in patients with obstructive airways diseases: an open, randomised, controlled comparison versus sobrerol.	2001 Aug	11535970
Action of neltenexine on anion secretion in human airway epithelia.	2007 May 18	17400191
Over-the-counter (OTC) medications to reduce cough as an adjunct to antibiotics for acute pneumonia in children and adults.	2007 Oct 17	17943884
Pharmacological and non-pharmacological interventions for cough in adults with respiratory and non-respiratory diseases: A systematic review of the literature.	2010 Jul	20385478

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:40:54 GMT 2023` Edited by `admin` on `Fri Dec 15 15:40:54 GMT 2023`
Record UNII	U942DGM90X
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NELTENEXINE

Official Name

English

Neltenexine [WHO-DD]

Common Name

English

4',6'-DIBROMO-.ALPHA.-((TRANS-4-HYDROXYCYCLOHEXYL)AMINO)-2-THIOPHENE-CARBOXY-O-TOLUIDIDE

Common Name

English

NELTENEXINE [MART.]

Common Name

English

neltenexine [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C74536