Plozasiran Sodium

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NCATS

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Wed Apr 02 13:26:29 GMT 2025` Edited by `admin` on `Wed Apr 02 13:26:29 GMT 2025`
Nucleic Acid Type	RNAI
Sequence Type	COMPLETE
Record UNII	U93HYZ4QU8
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ADS-005

Preferred Name

English

Plozasiran Sodium

Official Name

English

RNA, ([1?-de(6-amino-9H-purin-9-yl)]dA-(5??5?)-sp-Am-Cm-Gm-Gm-Gm-Am-Cm-Am-(2?-deoxy-2?-fluoro)G-(2?-deoxy-2?-fluoro)U-(2?-deoxy-2?-fluoro)A-Um-Um-Cm-Um-Cm-Am-Gm-Um-Im-Am-(3??3?)-sp-[1?-de(6-amino-9H-purin-9-yl)]dA), 3?-[O-[cis-4-[(3S,8S)-17-[[2-(acetylam

Common Name

English

ADS-005 SODIUM

Common Name

English

PLOZASIRAN SODIUM [USAN]

Common Name

English

Code System Code Type Description

FDA UNII

U93HYZ4QU8

Created by admin on Wed Apr 02 13:26:29 GMT 2025 , Edited by admin on Wed Apr 02 13:26:29 GMT 2025

PRIMARY

SMS_ID

300000052084

Created by admin on Wed Apr 02 13:26:29 GMT 2025 , Edited by admin on Wed Apr 02 13:26:29 GMT 2025

PRIMARY

CAS

2379776-41-5

Created by admin on Wed Apr 02 13:26:29 GMT 2025 , Edited by admin on Wed Apr 02 13:26:29 GMT 2025

PRIMARY

USAN

KL-220

Created by admin on Wed Apr 02 13:26:29 GMT 2025 , Edited by admin on Wed Apr 02 13:26:29 GMT 2025

PRIMARY

NCI_THESAURUS

C203192

Created by admin on Wed Apr 02 13:26:29 GMT 2025 , Edited by admin on Wed Apr 02 13:26:29 GMT 2025

PRIMARY

Sugar	Site Range	Site Count
2'-Fluoro-Ribose	1_10-1_12;2_2;2_4;2_12;2_14;2_16;2_18;2_20	10 / 44
2'-O-Methyl-Ribose	1_1-1_9;1_13-1_23;2_1;2_3;2_5-2_11;2_13;2_15;2_17;2_19;2_21	34 / 44

Linkage	Site Range	Site Count
Sodium Phosporothioate	1_22;2_2;2_4;2_21	4 / 42
	1_2-1_21;1_23;2_3;2_5-2_20	38 / 42

Related Record Type Details


					XG9ARL6P25

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOSIDE BASE SUBSTITUTION	[1_21]				HYPOXANTHINE	2TN51YD919
NUCLEOTIDE SUBSTITUTION	[1_23]				1,2-Dideoxy-D-ribofuranose 3-phosphorothioate sodium	ZF4XY3EE8G
NUCLEOTIDE SUBSTITUTION	[1_1]				UNSPECIFIED SUBSTANCE	fe518ce7 (not in database)