ALSEVALIMAB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 02:10:28 GMT 2025` Edited by `admin` on `Wed Apr 02 02:10:28 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	U8LYN0Y118
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ALSEVALIMAB

Official Name

English

alsevalimab [INN]

Preferred Name

English

IMMUNOGLOBULIN G1 (DE-450-LYSINE), ANTI-(HUMAN B7 HOMOLOG 4 PROTEIN) (HUMAN MONOCLONAL FPA150 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN MONOCLONAL FPA150 .KAPPA.CHAIN, DIMER

Systematic Name

English

FPA-150

Code

English

FPA150

Code

English

Code System Code Type Description

SMS_ID

300000023652

Created by admin on Wed Apr 02 02:10:28 GMT 2025 , Edited by admin on Wed Apr 02 02:10:28 GMT 2025

PRIMARY

INN

11301

Created by admin on Wed Apr 02 02:10:28 GMT 2025 , Edited by admin on Wed Apr 02 02:10:28 GMT 2025

PRIMARY

NCI_THESAURUS

C155967

Created by admin on Wed Apr 02 02:10:28 GMT 2025 , Edited by admin on Wed Apr 02 02:10:28 GMT 2025

PRIMARY

FDA UNII

U8LYN0Y118

Created by admin on Wed Apr 02 02:10:28 GMT 2025 , Edited by admin on Wed Apr 02 02:10:28 GMT 2025

PRIMARY

CAS

2254029-91-7

Created by admin on Wed Apr 02 02:10:28 GMT 2025 , Edited by admin on Wed Apr 02 02:10:28 GMT 2025

PRIMARY

From	To
1_22	1_97
1_147	1_203
1_223	3_214
1_229	2_229
1_232	2_232
1_264	1_324
1_370	1_428
2_22	2_97
2_147	2_203
2_223	4_214
2_264	2_324
2_370	2_428
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_300
N	2_300

Related Record Type Details


					CSK3SHL2SF

V-SET DOMAIN-CONTAINING T-CELL ACTIVATION INHIBITOR 1

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					U8LYN0Y118

ACTIVE MOIETY

Comments:

Immunomodulator

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	SITE_SPECIFIC			PIDOLIC ACID	SZB83O1W42
AMINO_ACID_SUBSTITUTION	[1_320] [1_412] [2_320] [2_412] [3_145] [4_145]	SITE_SPECIFIC			LYSINE	K3Z4F929H6
AMINO_ACID_SUBSTITUTION	[1_255] [2_255] [2_431] [3_4] [4_4]	SITE_SPECIFIC			METHIONINE SULFOXIDE	XN1XVI4B2C
AMINO ACID REMOVAL	[1_450] [2_450]	C-TERMINUS			LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL