CYCLORPHAN

OC1=CC2=C(C[C@@H]3[C@@H]4CCCC[C@]24CCN3CC5CC5)C=C1

InChIKey=NLBUEDSBXVNAPB-DFQSSKMNSA-N

InChI=1S/C20H27NO/c22-16-7-6-15-11-19-17-3-1-2-8-20(17,18(15)12-16)9-10-21(19)13-14-4-5-14/h6-7,12,14,17,19,22H,1-5,8-11,13H2/t17-,19+,20+/m0/s1

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

PubMed

Title	Date	PubMed
Aminothiazolomorphinans with mixed κ and μ opioid activity.	2011-03-24	21351746
Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors.	2010-01-14	19928862
In vivo characterization of (-)(-)MCL-144 and (+)(-)MCL-193: isomeric, bivalent ligands with mu/kappa agonist properties.	2008-10	18528756
In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors.	2007-06-15	17433695
High-affinity carbamate analogues of morphinan at opioid receptors.	2007-03-15	17276685
10-Ketomorphinan and 3-substituted-3-desoxymorphinan analogues as mixed kappa and micro opioid ligands: synthesis and biological evaluation of their binding affinity at opioid receptors.	2004-01-01	14695830
Tolerance to the analgesic effect of buprenorphine, butorphanol, nalbuphine, and cyclorphan, and cross-tolerance to morphine.	2001	14569437
Kappa opioid agonists as targets for pharmacotherapies in cocaine abuse.	2000-03	10812979

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:00:22 GMT 2025` Edited by `admin` on `Mon Mar 31 18:00:22 GMT 2025`
Record UNII	U6Z73N36V0
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

CYCLORPHAN

Common Name

English

(-)-CYCLORPHAN

Preferred Name

English

MORPHINAN-3-OL, 17-(CYCLOPROPYLMETHYL)-

Systematic Name

English

CYCLORPHAN [MI]

Common Name

English

17-(CYCLOPROPYLMETHYL)MORPHINAN-3-OL

Systematic Name

English

MORPHINAN, N-(CYCLOPROPYLMETHYL)-3-HYDROXY-

Systematic Name

English

Code System Code Type Description

ECHA (EC/EINECS)

224-007-5