CYCLORPHAN

[H][C@@]12CCCC[C@@]13CCN(CC4CC4)[C@@H]2CC5=CC=C(O)C=C35

InChIKey=NLBUEDSBXVNAPB-DFQSSKMNSA-N

InChI=1S/C20H27NO/c22-16-7-6-15-11-19-17-3-1-2-8-20(17,18(15)12-16)9-10-21(19)13-14-4-5-14/h6-7,12,14,17,19,22H,1-5,8-11,13H2/t17-,19+,20+/m0/s1

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

PubMed

Title	Date	PubMed
Kappa opioid agonists as targets for pharmacotherapies in cocaine abuse.	2000 Mar	10812979
Tolerance to the analgesic effect of buprenorphine, butorphanol, nalbuphine, and cyclorphan, and cross-tolerance to morphine.	2001	14569437
10-Ketomorphinan and 3-substituted-3-desoxymorphinan analogues as mixed kappa and micro opioid ligands: synthesis and biological evaluation of their binding affinity at opioid receptors.	2004 Jan 1	14695830
In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors.	2007 Jun 15	17433695
High-affinity carbamate analogues of morphinan at opioid receptors.	2007 Mar 15	17276685
In vivo characterization of (-)(-)MCL-144 and (+)(-)MCL-193: isomeric, bivalent ligands with mu/kappa agonist properties.	2008 Oct	18528756
Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors.	2010 Jan 14	19928862
Aminothiazolomorphinans with mixed κ and μ opioid activity.	2011 Mar 24	21351746

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:32:09 UTC 2023` Edited by `admin` on `Fri Dec 15 15:32:09 UTC 2023`
Record UNII	U6Z73N36V0
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

CYCLORPHAN

Common Name

English

MORPHINAN-3-OL, 17-(CYCLOPROPYLMETHYL)-

Systematic Name

English

CYCLORPHAN [MI]

Common Name

English

17-(CYCLOPROPYLMETHYL)MORPHINAN-3-OL

Systematic Name

English

(-)-CYCLORPHAN

Common Name

English

MORPHINAN, N-(CYCLOPROPYLMETHYL)-3-HYDROXY-

Systematic Name

English

Code System Code Type Description

ECHA (EC/EINECS)

224-007-5