ZIPEPROL HYDROCHLORIDE

Details

Stereochemistry	MIXED
Molecular Formula	C23H32N2O3.2ClH
Molecular Weight	457.434
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.Cl.COC(CN1CCN(CC(O)C(OC)C2=CC=CC=C2)CC1)C3=CC=CC=C3

InChI

InChIKey=MJKMHVIKCKUYTR-UHFFFAOYSA-N

InChI=1S/C23H32N2O3.2ClH/c1-27-22(19-9-5-3-6-10-19)18-25-15-13-24(14-16-25)17-21(26)23(28-2)20-11-7-4-8-12-20;;/h3-12,21-23,26H,13-18H2,1-2H3;2*1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C23H32N2O3
Molecular Weight	384.5118
Charge	0
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8889408 | https://www.ncbi.nlm.nih.gov/pubmed/9875445 | https://www.ncbi.nlm.nih.gov/pubmed/8934307 | https://www.ncbi.nlm.nih.gov/pubmed/10928682 |

Zipeprol is disubstituted piperazine that is marketed as a non-opioid antitussive in Europe, Asia, and South America. Zipeprol is not available in the United States or Canada and has been discontinued in Europe. Zipeprol is still available in some countries in Asia and South America. Zipeprol was demonstrated to have anticough effects in animal models, to be active as a blocker of histamine and cholinergic function, to be a potent local anesthetic and to possess bronchiospasmolytic actions. it had no remarkable cardiovascular or gastrointestinal actions in the rat or dog in comparison to codeine.

Approval Year

PubMed

Title	Date	PubMed

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:45:00 GMT 2023` Edited by `admin` on `Fri Dec 15 18:45:00 GMT 2023`
Record UNII	U6WT9D8ASL
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ZIPEPROL HYDROCHLORIDE

Common Name

English

ROBNIN

Brand Name

English

ZIPEPROL DIHYDROCHLORIDE

Common Name

English

.ALPHA.-(.ALPHA.-METHOXYBENZYL)-4-(BETA-METHOXYPHENETHYL)-1-PIPERAZINEETHANOL DIHYDROCHLORIDE

Systematic Name

English

Zipeprol dihydrochloride [WHO-DD]

Common Name

English

CERM-3024

Code

English

4-(2-METHOXY-2-PHENYLETHYL)-.ALPHA.-(METHOXYPHENYLMETHYL)-1-PIPERAZINEETHANOL DIHYDROCHLORIDE

Systematic Name

English

ZIPEPROL DIHYDROCHLORIDE [JAN]

Common Name

English

ZIPEPROL DIHYDROCHLORIDE [MI]

Common Name

English

ZIPEPROL HYDROCHLORIDE [MART.]

Common Name

English

Code System Code Type Description

EVMPD

SUB20786