ACITAZANOLAST MONOHYDRATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C9H7N5O3.H2O
Molecular Weight	251.1989
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O.OC(=O)C(=O)NC1=CC=CC(=C1)C2=NN=NN2

InChI

InChIKey=LEZMUVNSMYOTNL-UHFFFAOYSA-N

InChI=1S/C9H7N5O3.H2O/c15-8(9(16)17)10-6-3-1-2-5(4-6)7-11-13-14-12-7;/h1-4H,(H,10,15)(H,16,17)(H,11,12,13,14);1H2

HIDE SMILES / InChI

Molecular Formula	C9H7N5O3
Molecular Weight	233.1836
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	H2O
Molecular Weight	18.0153
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.dcchemicals.com/products_Show.asp?id=4171http://meds.qlifepro.com/detail/620006023/tazanolast
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/9150859

Tazanolast, an anti-allergic and anti-asthmatic agent with selective mast-cell stabilising effects, was developed jointly by Wakamoto and Torii Pharmaceuticals.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
histamine secretion by mast cell 3 Target ID: GO:0002553 Sources: http://www.ncbi.nlm.nih.gov/pubmed/9150859	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Asthma 241 Sources: http://meds.qlifepro.com/detail/620006023/tazanolast	Palliative		Approved 8429	Unknown Approved Use Unknown
Unknown 2578

PubMed

Title	Date	PubMed
[Effect of tazanolast on platelet activating factor-induced airway hyperresponsiveness in guinea pigs].	1992 Sep	1280089
Effect of an active metabolite of the antiallergic agent tazanolast on histamine release from rat mast cells.	1997 Apr	9150859

Patents

Sample Use Guides

In Vivo Use Guide

0.01 and 0.033% aerosol inhalation.

Route of Administration: Respiratory

In Vitro Use Guide

WP-871 (Acitazanolast) may inhibit histamine release mainly by preventing the increase in intracellular Ca2+ concentration

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:39:58 GMT 2023` Edited by `admin` on `Fri Dec 15 19:39:58 GMT 2023`
Record UNII	U6SU9ZSU4K
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ACITAZANOLAST MONOHYDRATE

Common Name

English

ACITAZANOLAST HYDRATE

Common Name

English

ACETIC ACID, 2-OXO-2-((3-(2H-TETRAZOL-5-YL)PHENYL)AMINO)-, HYDRATE (1:1)

Common Name

English

ZEPELIN

Brand Name

English

Acitazanolast monohydrate [WHO-DD]

Common Name

English

Code System Code Type Description

PUBCHEM

11954321