Apadamtase Alfa

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 09:19:35 GMT 2025` Edited by `admin` on `Wed Apr 02 09:19:35 GMT 2025`
Protein Type	ENZYME
Protein Sub Type	METALLOPROTEASE
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	U5SFU33XUX
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Apadamtase Alfa

Official Name

English

ADAMTS13 Q23, recombinant

Preferred Name

English

rADAMTS13 Q23

Preferred Name

English

rADAMTS-13 Q23

Code

English

A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 13 (RECOMBINANT)

Common Name

English

Metalloproteinase ADAMTS13 (human recombinant BAX930)

Common Name

English

Native rADAMTS13 Q23

Common Name

English

RECOMBINANT HUMAN ADAMTS13

Common Name

English

BAX930

Code

English

Apadamtase alfa [WHO-DD]

Common Name

English

SHP655

Code

English

apadamtase alfa [INN]

Common Name

English

RECOMBINANT ADAMTS-13

Common Name

English

ADAMTS13 Q23, RECOMBINANT HUMAN

Common Name

English

human metalloproteinase with thrombospondin motifs 13 (metalloproteinase ADAMTS13), produced in Chinese hamster ovary (CHO) cells, glycoform alfa

Common Name

English

SHP-655

Code

English

RECOMBINANT-A DISINTEGRIN AND MELLATOPROTEINASE WITH THROMBOSPONDIN TYPE-1 MOTIFS-13

Common Name

English

BAX-930

Code

English

TAK755

Code

English

TAK-755

Code

English

Classification Tree Code System Code

FDA ORPHAN DRUG

262208

Created by admin on Wed Apr 02 09:19:35 GMT 2025 , Edited by admin on Wed Apr 02 09:19:35 GMT 2025

EU-Orphan Drug

EU/3/08/588

Created by admin on Wed Apr 02 09:19:35 GMT 2025 , Edited by admin on Wed Apr 02 09:19:35 GMT 2025

FDA ORPHAN DRUG

265208

Created by admin on Wed Apr 02 09:19:35 GMT 2025 , Edited by admin on Wed Apr 02 09:19:35 GMT 2025

FDA ORPHAN DRUG

768720

Created by admin on Wed Apr 02 09:19:35 GMT 2025 , Edited by admin on Wed Apr 02 09:19:35 GMT 2025

Code System Code Type Description

CAS

2086325-24-6

Created by admin on Wed Apr 02 09:19:35 GMT 2025 , Edited by admin on Wed Apr 02 09:19:35 GMT 2025

PRIMARY

FDA UNII

U5SFU33XUX

Created by admin on Wed Apr 02 09:19:35 GMT 2025 , Edited by admin on Wed Apr 02 09:19:35 GMT 2025

PRIMARY

USAN

KL-66

Created by admin on Wed Apr 02 09:19:35 GMT 2025 , Edited by admin on Wed Apr 02 09:19:35 GMT 2025

PRIMARY

INN

10765

Created by admin on Wed Apr 02 09:19:35 GMT 2025 , Edited by admin on Wed Apr 02 09:19:35 GMT 2025

PRIMARY

WIKIPEDIA

ADAMTS13

Created by admin on Wed Apr 02 09:19:35 GMT 2025 , Edited by admin on Wed Apr 02 09:19:35 GMT 2025

PRIMARY

NCI_THESAURUS

C169784

Created by admin on Wed Apr 02 09:19:35 GMT 2025 , Edited by admin on Wed Apr 02 09:19:35 GMT 2025

PRIMARY

SMS_ID

100000181754

Created by admin on Wed Apr 02 09:19:35 GMT 2025 , Edited by admin on Wed Apr 02 09:19:35 GMT 2025

PRIMARY

DRUG BANK

DB15164

Created by admin on Wed Apr 02 09:19:35 GMT 2025 , Edited by admin on Wed Apr 02 09:19:35 GMT 2025

PRIMARY

DAILYMED

U5SFU33XUX

Created by admin on Wed Apr 02 09:19:35 GMT 2025 , Edited by admin on Wed Apr 02 09:19:35 GMT 2025

PRIMARY

From	To
1_81	1_134
1_128	1_207
1_168	1_191
1_237	1_263
1_248	1_273
1_258	1_292
1_286	1_297
1_322	1_359
1_326	1_364
1_337	1_349
1_376	1_413
1_409	1_448
1_434	1_453
1_458	1_474
1_471	1_481

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_68
N	1_72
N	1_478
N	1_505
N	1_540
N	1_593
N	1_633
N	1_754
N	1_1161
N	1_1280
O	1_325
O	1_624
O	1_683
O	1_833
O	1_891
O	1_953
O	1_1013

Related Record Type Details


					ZE22NE22F1

VON WILLEBRAND FACTOR HUMAN

SUBSTRATE->ENZYME

Amount:


					ZE22NE22F1

VON WILLEBRAND FACTOR HUMAN

TARGET -> SUBSTRATE

Comments:

ADAMTS-13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) is a constitutively active enzyme that cleaves von Willebrand factor (VWF) at the Tyr1605–Met1606 bond in the A2 domai

Amount:


					ZE22NE22F1

VON WILLEBRAND FACTOR HUMAN

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					U5SFU33XUX

Apadamtase Alfa

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
METAL_BINDING	[1_150] [1_154] [1_160]	SITE_SPECIFIC			ZINC CATION	13S1S8SF37
METAL_BINDING	[1_108] [1_110] [1_113] [1_138]	SITE_SPECIFIC			CALCIUM CATION	2M83C4R6ZB

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT	CHEMICAL
Molecular Formula	CHEMICAL