Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C18H23NO7S.2Na |
Molecular Weight | 443.422 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].[Na+].COCCOCCOCCOC1=CC=CC(C2=N[C@](C)(CS2)C([O-])=O)=C1[O-]
InChI
InChIKey=ZGUSTINUKQHFCO-JPKZNVRTSA-L
InChI=1S/C18H25NO7S.2Na/c1-18(17(21)22)12-27-16(19-18)13-4-3-5-14(15(13)20)26-11-10-25-9-8-24-7-6-23-2;;/h3-5,20H,6-12H2,1-2H3,(H,21,22);;/q;2*+1/p-2/t18-;;/m1../s1
Molecular Formula | C18H23NO7S |
Molecular Weight | 397.443 |
Charge | -2 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Molecular Formula | Na |
Molecular Weight | 22.9898 |
Charge | 1 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Deferitazole is an iron chelator, developed by the FerroKin BioSciences (later acquired by Shire, and then by Takeda). Deferitazole is a member of the desazadesferrithiocin class of siderophore-related tridentate chelators. It binds Fe(III) with very high affinity and selectivity over Fe(II) and other biologically important metals. Deferitazole was investigated in phase 2 clinical trials in patients with iron overload due to repeated red blood cell transfusion and beta-thalassemia, however, the development of the drug was discontinued. In preclinical models, deferitazole demonstrated efficacy for the treatment and prevention of malaria.
Approval Year
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 10:12:42 GMT 2023
by
admin
on
Sat Dec 16 10:12:42 GMT 2023
|
Record UNII |
U5SD55XZY8
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English |
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
U5SD55XZY8
Created by
admin on Sat Dec 16 10:12:42 GMT 2023 , Edited by admin on Sat Dec 16 10:12:42 GMT 2023
|
PRIMARY | |||
|
71599794
Created by
admin on Sat Dec 16 10:12:42 GMT 2023 , Edited by admin on Sat Dec 16 10:12:42 GMT 2023
|
PRIMARY |
Related Record | Type | Details | ||
---|---|---|---|---|
|
PARENT -> SALT/SOLVATE |
Related Record | Type | Details | ||
---|---|---|---|---|
|
ACTIVE MOIETY |