Approval Year
Related Record | Type | Details |
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Related Record | Type | Details | ||
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ACTIVE MOIETY |
The underlying mode of action of this
molecule is to enhance the effector function of tumor-infiltrating T-cells or NK-cells upon
activation by a tumor-targeted T-cell bispecific (TCB) antibody or antibody-dependent cellular cytotoxicity (ADCC), respectively, by crosslinking 4-1BB-positive activated effector cells with CD19+ tumor targets.
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Structural Modifications
Modification Type | Location Site | Location Type | Residue Modified | Extent | Fragment Name | Fragment Approval |
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Modification Type | Location Site | Location Type | Residue Modified | Extent | Fragment Name | Fragment Approval |
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AMINO_ACID_SUBSTITUTION | [2_1] | N-TERMINUS | PIDOLIC ACID | SZB83O1W42 | ||
AMINO ACID REMOVAL | [1_710] [2_451] | C-TERMINUS | LYSINE | K3Z4F929H6 |
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Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
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Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
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Molecular Formula | CHEMICAL |
ESTIMATED
C7979H12501O2456N2170S42 |
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MOL_WEIGHT:NUMBER(CALCULATED) | CHEMICAL |
179183.6 DALTONS (average) Intact, -K, +Pyroglu |
Showing 1 to 2 of 2 entries