U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 18:47:31 GMT 2023
Edited
by admin
on Sat Dec 16 18:47:31 GMT 2023
Protein Type BISPECIFIC ANTIBODY
Protein Sub Type IGG1
Sequence Type COMPLETE
Record UNII
U4T9GD9GR9
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Englumafusp Alfa
USAN   INN  
Official Name English
RO-7227166
Code English
englumafusp alfa [INN]
Common Name English
RO7227166
Code English
71-248-4-1BB ligand (human precursor) fusion protein with peptide linker (GGGGS)2 fusion protein with 71-248-4-1BB ligand (human precursor) peptide linker (GGGGS)2 fusion protein with human κ-chain C region fusion protein with immunoglobulin G1 [497-ala
Common Name English
ENSOMAFUSP ALFA [USAN]
Common Name English
ENGLUMAFUSP ALFA [USAN]
Common Name English
RG6076
Code English
humanized immunoglobulin G1-kappa anti-(human B-lymphocyte antigen CD19) modified heterodimer where the heavy and light chain variable regions of one arm have been substituted by three subunits of human 4- 1BB ligand (tumor necrosis factor ligand superfa
Common Name English
ENSOMAFUSP ALFA
INN   USAN  
Official Name English
RG-6076
Code English
RO 7227166 [WHO-DD]
Common Name English
humanized immunoglobulin G1-kappa anti-(human B-lymphocyte antigen CD19) modified heterodimer where the heavy and light chain variable regions of one arm have been substituted by three subunits of human 4- 1BB ligand (tumor necrosis factor ligand superfa
Common Name English
Code System Code Type Description
NCI_THESAURUS
C169052
Created by admin on Sat Dec 16 18:47:31 GMT 2023 , Edited by admin on Sat Dec 16 18:47:31 GMT 2023
PRIMARY
FDA UNII
U4T9GD9GR9
Created by admin on Sat Dec 16 18:47:31 GMT 2023 , Edited by admin on Sat Dec 16 18:47:31 GMT 2023
PRIMARY
INN
11793
Created by admin on Sat Dec 16 18:47:31 GMT 2023 , Edited by admin on Sat Dec 16 18:47:31 GMT 2023
PRIMARY
CAS
2417199-08-5
Created by admin on Sat Dec 16 18:47:31 GMT 2023 , Edited by admin on Sat Dec 16 18:47:31 GMT 2023
PRIMARY
USAN
KL-61
Created by admin on Sat Dec 16 18:47:31 GMT 2023 , Edited by admin on Sat Dec 16 18:47:31 GMT 2023
PRIMARY
From To
1_617 2_353
4_139 4_199
4_23 4_93
3_215 3_271
1_492 2_233
1_489 2_230
2_371 2_429
2_265 2_325
2_224 4_219
2_148 2_204
2_22 2_96
1_483 3_291
1_630 1_688
1_524 1_584
1_403 1_463
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_560
N 2_301
Related Record Type Details
ACTIVE MOIETY
The underlying mode of action of this molecule is to enhance the effector function of tumor-infiltrating T-cells or NK-cells upon activation by a tumor-targeted T-cell bispecific (TCB) antibody or antibody-dependent cellular cytotoxicity (ADCC), respectively, by crosslinking 4-1BB-positive activated effector cells with CD19+ tumor targets.
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL