Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C12H3Cl5O |
| Molecular Weight | 340.417 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
ClC1=CC2=C(C=C1Cl)C3=C(O2)C(Cl)=C(Cl)C(Cl)=C3
InChI
InChIKey=OGBQILNBLMPPDP-UHFFFAOYSA-N
InChI=1S/C12H3Cl5O/c13-6-1-4-5-2-8(15)10(16)11(17)12(5)18-9(4)3-7(6)14/h1-3H
| Molecular Formula | C12H3Cl5O |
| Molecular Weight | 340.417 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Consensus toxicity factors for polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls combining in silico models and extensive in vitro screening of AhR-mediated effects in human and rodent cells. | 2015-04-20 |
|
| Functionality of aryl hydrocarbon receptors (AhR1 and AhR2) of white sturgeon (Acipenser transmontanus) and implications for the risk assessment of dioxin-like compounds. | 2014-07-15 |
|
| Relative potency for altered humoral immunity induced by polybrominated and polychlorinated dioxins/furans in female B6C3F1/N mice. | 2014-06 |
|
| Differential relative effect potencies of some dioxin-like compounds in human peripheral blood lymphocytes and murine splenic cells. | 2014-04-07 |
|
| A genomics-based analysis of relative potencies of dioxin-like compounds in primary rat hepatocytes. | 2013-12 |
|
| Comparison of intake and systemic relative effect potencies of dioxin-like compounds in female mice after a single oral dose. | 2013-07 |
|
| Amino acid sequence of the ligand-binding domain of the aryl hydrocarbon receptor 1 predicts sensitivity of wild birds to effects of dioxin-like compounds. | 2013-01 |
|
| Third-generation Ah receptor-responsive luciferase reporter plasmids: amplification of dioxin-responsive elements dramatically increases CALUX bioassay sensitivity and responsiveness. | 2011-10 |
|
| Transcriptional profiles induced by the Aryl Hydrocarbon Receptor agonists 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran and 2,3,4,7,8-pentachlorodibenzofuran in primary rat hepatocytes. | 2011-09 |
|
| Differential ligand-dependent activation and a role for Y322 in aryl hydrocarbon receptor-mediated regulation of gene expression. | 2011-07-15 |
|
| Sensitivity of Japanese quail (Coturnix japonica), Common pheasant (Phasianus colchicus), and White Leghorn chicken (Gallus gallus domesticus) embryos to in ovo exposure to TCDD, PeCDF, and TCDF. | 2011-01 |
|
| Thyroid follicular lesions induced by oral treatment for 2 years with 2,3,7,8-tetrachlorodibenzo-p-dioxin and dioxin-like compounds in female Harlan Sprague-Dawley rats. | 2010-12 |
|
| Human and rat primary hepatocyte CYP1A1 and 1A2 induction with 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran, and 2,3,4,7,8-pentachlorodibenzofuran. | 2010-11 |
|
| 2,3,4,7,8-pentachlorodibenzofuran is a more potent cytochrome P4501A inducer than 2,3,7,8-tetrachlorodibenzo-p-dioxin in herring gull hepatocyte cultures. | 2010-09 |
|
| Case report: the University of Michigan dioxin exposure study: a follow-up investigation of a case with high serum concentration of 2,3,4,7,8-pentachlorodibenzofuran. | 2010-09 |
|
| Effects of in ovo exposure of white leghorn chicken, common pheasant, and Japanese quail to 2,3,7,8-tetrachlorodibenzo-p-dioxin and two chlorinated dibenzofurans on CYP1A induction. | 2010-07 |
|
| Ethoxyresorufin O-deethylase induction by TCDD, PeCDF and TCDF in ring-necked pheasant and Japanese quail hepatocytes: Time-dependent effects on concentration-response curves. | 2010-06 |
|
| Twenty-year changes of penta-chlorodibenzofuran (PeCDF) level and symptoms in Yusho patients, using association analysis. | 2010-05-05 |
|
| Passerine exposure to primarily PCDFs and PCDDs in the river floodplains near Midland, Michigan, USA. | 2010-05 |
|
| Cytochrome P4501A induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin and two chlorinated dibenzofurans in primary hepatocyte cultures of three avian species. | 2010-02 |
|
| Reproductive lesions in female Harlan Sprague-Dawley rats following two-year oral treatment with dioxin and dioxin-like compounds. | 2009-12 |
|
| Variation in half-life of penta-chlorodibenzofuran (PeCDF) blood level among Yusho patients. | 2009-10 |
|
| The aryl hydrocarbon receptor as a target for estrogen receptor-negative breast cancer chemotherapy. | 2009-09 |
|
| Aryl hydrocarbon receptor activation and overexpression upregulated fibroblast growth factor-9 in human lung adenocarcinomas. | 2009-08-15 |
|
| Impact of WHO 2005 revised toxic equivalency factors for dioxins on the TEQs in serum, household dust and soil. | 2009-08 |
|
| Hepatic P450 enzyme activity, tissue morphology and histology of mink (Mustela vison) exposed to polychlorinated dibenzofurans. | 2009-08 |
|
| [The accelerated excretion of 2,3,4,7,8-pentachlorodibenzofuran by Cholebine]. | 2009-05 |
|
| [Estimated half-life of penta-chlorodibenzofuran (PeCDF) and simulation of PeCDF excretion]. | 2009-05 |
|
| [Differential correlation of medical/laboratory examinations with blood levels of polychlorinated biphenyls, polychlorinated quarterphenyls and 2,3,4,7,8-pentachlorodibenzofuran in Yusho patients from 2001 to 2004]. | 2009-05 |
|
| [Lymphocyte subpopulations in patients with Yusho]. | 2009-05 |
|
| Prevalence of metabolic syndrome associated with body burden levels of dioxin and related compounds among Japan's general population. | 2009-04 |
|
| Cutaneous symptoms such as acneform eruption and pigmentation are closely associated with blood levels of 2,3,4,7,8-penta-chlorodibenzofurans in Yusho patients, using data mining analysis. | 2009-02-25 |
|
| Sequencing and characterization of mixed function monooxygenase genes CYP1A1 and CYP1A2 of Mink (Mustela vison) to facilitate study of dioxin-like compounds. | 2009-02-01 |
|
| Estimates of cancer potency of 2,3,4,7,8-pentachlorodibenzofuran using both nonlinear and linear approaches. | 2008-12 |
|
| Association of organochlorine pesticides with peripheral neuropathy in patients with diabetes or impaired fasting glucose. | 2008-11 |
|
| Association of clinical findings in Yusho patients with serum concentrations of polychlorinated biphenyls, polychlorinated quarterphenyls and 2,3,4,7,8-pentachlorodibenzofuran more than 30 years after the poisoning event. | 2008-10-02 |
|
| Identification of the functional domain of thyroid hormone receptor responsible for polychlorinated biphenyl-mediated suppression of its action in vitro. | 2008-09 |
|
| Toxicokinetics of 2,3,7,8-TCDF and 2,3,4,7,8-PeCDF in mink (Mustela vison) at ecologically relevant exposures. | 2008-09 |
|
| Long-term effects of polychlorinated biphenyls and dioxins on pregnancy outcomes in women affected by the Yusho incident. | 2008-05 |
|
| Screening of 397 chemicals and development of a quantitative structure--activity relationship model for androgen receptor antagonism. | 2008-04 |
|
| Relative potency based on hepatic enzyme induction predicts immunosuppressive effects of a mixture of PCDDS/PCDFS and PCBS. | 2008-03-15 |
|
| Ligand-dependent interactions of the Ah receptor with coactivators in a mammalian two-hybrid assay. | 2008-03-01 |
|
| Pulmonary lesions in female Harlan Sprague-Dawley rats following two-year oral treatment with dioxin-like compounds. | 2007-12 |
|
| A critical comparison of murine pathology and epidemiological data of TCDD, PCB126, and PeCDF. | 2007-12 |
|
| [The past history of diseases and symptoms among the Yusho patients, and its association with blood lipid concentration of 2,3,4,7,8-pentachlorodibenzofuran]. | 2007-05 |
|
| [Relationship between blood dioxin levels and present/past clinical symptoms in Kanemi Yusho patients]. | 2007-05 |
|
| [Average of the PCDFs value in blood in patients with Yusho in the 2001 to 2003 fiscal year and comparison between the clinical features and PCDFs]. | 2007-05 |
|
| Role of CYP1A2 in hepatic sequestration of dioxin: studies using CYP1A2 knock-out mice. | 1997-07-18 |
|
| Promotion of endometriosis in mice by polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls. | 1997-07 |
|
| Decreased ligand binding to the hepatic glucocorticoid and epidermal growth factor receptors after 2,3,4,7,8-pentachlorodibenzofuran and 1,2,3,4,7,8-hexachlorodibenzofuran treatment of pregnant mice. | 1989-05 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 19:15:22 GMT 2025
by
admin
on
Mon Mar 31 19:15:22 GMT 2025
|
| Record UNII |
U4C2RV3124
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
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7178
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DTXSID7030066
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m8954
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57117-31-4
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42128
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U4C2RV3124
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