GESTONORONE CAPROATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C26H38O4
Molecular Weight	414.5775
Optical Activity	UNSPECIFIED
Defined Stereocenters	6 / 6
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12CC[C@](OC(=O)CCCCC)(C(C)=O)[C@@]1(C)CC[C@]3([H])[C@@]4([H])CCC(=O)C=C4CC[C@@]23[H]

InChI

InChIKey=XURCMZMFZXXQDJ-UKNJCJGYSA-N

InChI=1S/C26H38O4/c1-4-5-6-7-24(29)30-26(17(2)27)15-13-23-22-10-8-18-16-19(28)9-11-20(18)21(22)12-14-25(23,26)3/h16,20-23H,4-15H2,1-3H3/t20-,21+,22+,23-,25-,26-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C26H38O4
Molecular Weight	414.5775
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	6 / 6
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: http://www.ncbi.nlm.nih.gov/pubmed/4117437
Curator's Comment: description was created based on several sources, including, http://www.medicamentos.com.mx/DocHTM/22255.htm

Gestonorone is a progesterone analogue indicated for the treatment of benign prostatic hyperplasia and endometrial cancer. The drug is approved in many countries and used under the names Primostat and Depostat.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Benign prostatic hyperplasia 28 Sources: http://www.medicamentos.com.mx/dochtm/18423.htm	Primary		Approved 8429	PRIMOSTAT Approved Use Conservative treatment of benign prostatic hyperplasia and palliative treatment of severe endometrial cancer.
Endometrial cancer 43 Sources: http://www.medicamentos.com.mx/dochtm/18423.htm	Palliative		Approved 8429	PRIMOSTAT Approved Use Conservative treatment of benign prostatic hyperplasia and palliative treatment of severe endometrial cancer.

PubMed

Title	Date	PubMed
Gestronol hexanoate (SH582) and benign prostatic hypertrophy.	1972 Feb	4117436
Clinical trial of gestronol hexanoate (SH582) in benign prostatic hypertrophy.	1972 Feb	4117437
Adjuvant hormonal therapy for stage I endometrial cancer.	2008 Jun	18596890

Patents

Sample Use Guides

In Vivo Use Guide

Slow intramuscular injection of 200 mg every week for 2 to 3 months.

Route of Administration: Intramuscular

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:07:18 GMT 2023` Edited by `admin` on `Fri Dec 15 15:07:18 GMT 2023`
Record UNII	U38E620NS6
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

GESTONORONE CAPROATE

Official Name

English

GESTONORONE CAPROATE [JAN]

Common Name

English

DEPOSTAT

Brand Name

English

NSC-84054

Code

English

GESTRONOL HEXANOATE

Common Name

English

GESTONORONE HEXANOATE

Common Name

English

gestonorone caproate [INN]

Common Name

English

GESTONORONE CAPROATE [USAN]

Common Name

English

17-Hydroxy-19-norpregn-4-ene-3,20-dione hexanoate

Common Name

English

19-NORPREGN-4-ENE-3,20-DIONE, 17-((1-OXOHEXYL)OXY)-

Common Name

English

SH-582

Code

English

GESTONORONE CAPROATE [MART.]

Common Name

English

SH 582

Code

English

GESTONORONE CAPROATE [MI]

Common Name

English

Gestonorone caproate [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C776