MOXAZOCINE, (±)- TARTRATE

Details

Stereochemistry	MIXED
Molecular Formula	2C18H25NO2.C4H6O6
Molecular Weight	724.88
Optical Activity	UNSPECIFIED
Defined Stereocenters	8 / 8
E/Z Centers	0
Charge	0
Stereo Comments	Moxazocine is racemic and Tartaric acid chiral

SHOW SMILES / InChI

Structure Search

SMILES

O[C@H]([C@@H](O)C(O)=O)C(O)=O.CO[C@H]1[C@H]2CC3=CC=C(O)C=C3[C@]1(C)CCN2CC4CC4.CO[C@H]5[C@H]6CC7=CC=C(O)C=C7[C@]5(C)CCN6CC8CC8

InChI

InChIKey=PUBVUBRYUIOBTJ-DAORBUFXSA-N

InChI=1S/2C18H25NO2.C4H6O6/c2*1-18-7-8-19(11-12-3-4-12)16(17(18)21-2)9-13-5-6-14(20)10-15(13)18;5-1(3(7)8)2(6)4(9)10/h2*5-6,10,12,16-17,20H,3-4,7-9,11H2,1-2H3;1-2,5-6H,(H,7,8)(H,9,10)/t2*16-,17+,18+;1-,2-/m111/s1

HIDE SMILES / InChI

Molecular Formula	C4H6O6
Molecular Weight	150.0868
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	C18H25NO2
Molecular Weight	287.3966
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2822190 | https://www.ncbi.nlm.nih.gov/pubmed/6865909

Moxazocine is a benzomorphan derivative patented by Bristol-Myers Co. as potent opioid analgesic. Moxazocine acts as a partial agonist or mixed agonist/antagonist of the opioid receptors and binds preferentially to the κ-opioid receptor. In clinical studies, Moxazocine demonstrated superior efficacy compared morphine, but was never marketed.

Originator

Approval Year

PubMed

Title	Date	PubMed
Differential sensitivity of models of antinociception in the rat, mouse and guinea-pig to mu- and kappa-opioid receptor agonists.	1987-08	2822190

Patents

Sample Use Guides

In Vivo Use Guide

0.5 and 1.0 mg

Route of Administration: Intravenous

Substance Class	Chemical Created by `admin` on `Tue Apr 01 22:00:31 GMT 2025` Edited by `admin` on `Tue Apr 01 22:00:31 GMT 2025`
Record UNII	U208HJA2N3
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MOXAZOCINE, (±)- TARTRATE

Common Name

English

2,6-METHANO-3-BENZAZOCIN-8-OL, 3-(CYCLOPROPYLMETHYL)-1,2,3,4,5,6-HEXAHYDRO-11-METHOXY-6-METHYL-, (2R-(2.ALPHA.,6.ALPHA.,11R*))-, (2R,3R)-2,3-DIHYDROXYBUTANEDIOATE (2:1) (SALT)

Preferred Name

English

Code System Code Type Description

FDA UNII

U208HJA2N3

Created by admin on Tue Apr 01 22:00:31 GMT 2025 , Edited by admin on Tue Apr 01 22:00:31 GMT 2025

PRIMARY

CAS

58266-96-9