Efdoralprin Alfa

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 05:30:28 GMT 2025` Edited by `admin` on `Wed Apr 02 05:30:28 GMT 2025`
Protein Type	FC FUSION PROTEIN
Protein Sub Type	IGG4
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	TYK0A4WR1D
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Efdoralprin Alfa

Official Name

English

IgG4 Fc linked recombinant human alpha-1 antitrypsin

Preferred Name

English

?1-Antitrypsin [351-glutamic acid,358-leucine] (human) fusion protein with peptide linker (GS) fusion protein with immunoglobulin G4 [406-proline,413-glutamic acid,430-tyrosine,606-leucine] (human ?4-chain C region C-terminal fragment), dimer

Common Name

English

efdoralprin alfa [INN]

Common Name

English

human alpha-1-antitrypsin (alpha-1 protease inhibitor, serpin A1, AAT) (1-394), variant (M<sup>351</sup>>E, M<sup>358</sup>>L) fused via peptide linker <sup>395</sup>GS<sup>396</sup> to an Fc fragment of human immunoglobulin G4 (397-625) [Homo sapiens IG

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

863521

Created by admin on Wed Apr 02 05:30:28 GMT 2025 , Edited by admin on Wed Apr 02 05:30:28 GMT 2025

Code System Code Type Description

SMS_ID

300000027211

Created by admin on Wed Apr 02 05:30:28 GMT 2025 , Edited by admin on Wed Apr 02 05:30:28 GMT 2025

PRIMARY

INN

13115

Created by admin on Wed Apr 02 05:30:28 GMT 2025 , Edited by admin on Wed Apr 02 05:30:28 GMT 2025

PRIMARY

FDA UNII

TYK0A4WR1D

Created by admin on Wed Apr 02 05:30:28 GMT 2025 , Edited by admin on Wed Apr 02 05:30:28 GMT 2025

PRIMARY

NCI_THESAURUS

C211809

Created by admin on Wed Apr 02 05:30:28 GMT 2025 , Edited by admin on Wed Apr 02 05:30:28 GMT 2025

PRIMARY

CAS

2539844-42-1

Created by admin on Wed Apr 02 05:30:28 GMT 2025 , Edited by admin on Wed Apr 02 05:30:28 GMT 2025

PRIMARY

From	To
1_407	2_407
1_404	2_404
2_545	2_603
2_439	2_499
1_545	1_603
1_439	1_499

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_46
N	1_83
N	1_247
N	1_475
N	2_46
N	2_83
N	2_247
N	2_475

Related Record Type Details


					TYK0A4WR1D

Efdoralprin Alfa

ACTIVE MOIETY

Comments:

alpha-1 antitrypsin homologue

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_625] [2_625]	C-TERMINUS			LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL