Thenium closylate

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H20NOS.C6H4ClO3S
Molecular Weight	454.003
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[O-]S(=O)(=O)C1=CC=C(Cl)C=C1.C[N+](C)(CCOC2=CC=CC=C2)CC3=CC=CS3

InChI

InChIKey=QMAHSUSUOMSSBK-UHFFFAOYSA-M

InChI=1S/C15H20NOS.C6H5ClO3S/c1-16(2,13-15-9-6-12-18-15)10-11-17-14-7-4-3-5-8-14;7-5-1-3-6(4-2-5)11(8,9)10/h3-9,12H,10-11,13H2,1-2H3;1-4H,(H,8,9,10)/q+1;/p-1

HIDE SMILES / InChI

Molecular Formula	C15H20NOS
Molecular Weight	262.39
Charge	1
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C6H4ClO3S
Molecular Weight	191.612
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/15313135 | https://www.ncbi.nlm.nih.gov/pubmed/13875028 | http://pocayo.com/Tutorial/topic-212/Veterinary-Procedures-and-Emergency-Treatment-737.html

Cholinergic anthelmintic, Thenium is used against dog and cat hookworms.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
acetylcholine metabolic process 11 Target ID: GO:0008291 Sources: https://www.ncbi.nlm.nih.gov/pubmed/629460 \| https://www.ncbi.nlm.nih.gov/pubmed/15313135 \| https://www.ncbi.nlm.nih.gov/pubmed/19295856 \| https://link.springer.com/referenceworkentry/10.1007/3-540-29835-5_2008	Modulator 828

Conditions

Condition	Modality	Targets	Highest Phase	Product
Helminthiasis 39 Sources: https://www.ncbi.nlm.nih.gov/pubmed/629460 https://www.ncbi.nlm.nih.gov/pubmed/13875028 https://www.ncbi.nlm.nih.gov/pubmed/629460	Curative		Approved 8429	CANOPAR Approved Use Antiparasitic; hookworms Launch Date 1961

PubMed

Title	Date	PubMed
Oxantel is an N-type (methyridine and nicotine) agonist not an L-type (levamisole and pyrantel) agonist: classification of cholinergic anthelmintics in Ascaris.	2004 Aug	15313135

Patents

Sample Use Guides

In Vivo Use Guide

Dog: >4.5 kg, 500 mg PO once and repeat in 2-3 wk; 2.5-4.5 kg, 250 mg q12h for 1 day and repeat in 2-3 wk

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:03:04 GMT 2023` Edited by `admin` on `Sat Dec 16 17:03:04 GMT 2023`
Record UNII	TU308VI4JY
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

Thenium closylate

Official Name

English

2-THIOPHENEMETHANAMINIUM, N,N-DIMETHYL-N-(2-PHENOXYETHYL)-, SALT WITH 4-CHLOROBENZENESULFONIC ACID (1:1)

Common Name

English

THENIUM CLOSILATE

Official Name

English

THENIUM CLOSYLATE [GREEN BOOK]

Common Name

English

DIMETHYL(2-PHENOXYETHYL)-2-THENYLAMMONIUM P-CHLOROBENZENESULPHONATE

Common Name

English

THENIUM CLOSYLATE [USAN]

Common Name

English

thenium closilate [INN]

Common Name

English

THENIUM CLOSILATE [MART.]

Common Name

English

DIMETHYL(2-PHENOXYETHYL)-2-THENYLAMMONIUM P-CHLOROBENZENESULFONATE

Common Name

English

NSC-106569

Code

English

THENIUM CLOSYLATE [MI]

Common Name

English

611-C-65

Code

English

611 C 65

Code

English

Classification Tree Code System Code

CFR

21 CFR 520.2362