FURA-2

Details

Stereochemistry	ACHIRAL
Molecular Formula	C29H27N3O14
Molecular Weight	641.5364
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=CC=C(N(CC(O)=O)CC(O)=O)C(OCCOC2=CC3=C(OC(=C3)C4=NC=C(O4)C(O)=O)C=C2N(CC(O)=O)CC(O)=O)=C1

InChI

InChIKey=YFHXZQPUBCBNIP-UHFFFAOYSA-N

InChI=1S/C29H27N3O14/c1-15-2-3-17(31(11-24(33)34)12-25(35)36)20(6-15)43-4-5-44-21-7-16-8-22(28-30-10-23(46-28)29(41)42)45-19(16)9-18(21)32(13-26(37)38)14-27(39)40/h2-3,6-10H,4-5,11-14H2,1H3,(H,33,34)(H,35,36)(H,37,38)(H,39,40)(H,41,42)

HIDE SMILES / InChI

Molecular Formula	C29H27N3O14
Molecular Weight	641.5364
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
A spirochete surface protein uncouples store-operated calcium channels in fibroblasts: a novel cytotoxic mechanism.	2001-06-22	11312269
Molecular cloning of a third member of the potassium-dependent sodium-calcium exchanger gene family, NCKX3.	2001-06-22	11294880
Reassessment of the Ca2+ sensing property of a type I metabotropic glutamate receptor by simultaneous measurement of inositol 1,4,5-trisphosphate and Ca2+ in single cells.	2001-06-01	11278354
The anti-inflammatory interactions of epinephrine with human neutrophils in vitro are achieved by cyclic AMP-mediated accelerated resequestration of cytosolic calcium.	2001-05-15	11322936
Mobilization of calcium from intracellular stores, potentiation of neurotransmitter-induced calcium transients, and capacitative calcium entry by 4-aminopyridine.	2001-05-01	11312298
Inhibition of ATP-induced surfactant exocytosis by dihydropyridine (DHP) derivatives: a non-stereospecific, photoactivated effect and independent of L-type Ca2+ channels.	2001-05-01	11301050
The properties of ryanodine-sensitive Ca(2+) release in mouse gastric smooth muscle cells.	2001-05	11325802
Proteasomal activation mediates down-regulation of inositol 1,4,5-trisphosphate receptor and calcium mobilization in rat pancreatic islets.	2001-05	11316737
Effects of luminal shear stress on cerebral arteries and arterioles.	2001-05	11299201
Agonist activation of cytosolic Ca2+ in subfornical organ cells projecting to the supraoptic nucleus.	2001-05	11294785
Ca(2+) entry into primary cultured pig coronary smooth muscle cells after previous store depletion by repetitive P2Y purinoceptor stimulation.	2001-05	11292392
InsP(3)-induced Ca(2+) release in permeabilized invertebrate photoreceptors: a link between phototransduction and Ca(2+) stores.	2001-05	11292390
Analysis of Mn(2+)/Ca(2+) influx and release during Ca(2+) oscillations in mouse eggs injected with sperm extract.	2001-05	11292388
Functional receptor-channel coupling compared in contractile and proliferative human vascular smooth muscle.	2001-05	11268004
Angiotensin II type I receptor modulates intracellular free Mg2+ in renally derived cells via Na+-dependent Ca2+-independent mechanisms.	2001-04-27	11278387
Contribution of the plasmalemma to Ca2+ homeostasis in hair cells.	2001-04-15	11306617
Sperm factor initiates capacitance and conductance changes in mouse eggs that are more similar to fertilization than IP(3)- or Ca(2+)-induced changes.	2001-04-01	11254353
Greater inhibition of platelet procoagulant activity by antibody-derived glycoprotein IIb--IIIa inhibitors than by peptide and peptidomimetic inhibitors.	2001-04	11328283
Blunted adenosine A2a receptor function in platelets in patients with major depression.	2001-04	11313166
Prion protein affects Ca2+-activated K+ currents in cerebellar purkinje cells.	2001-04	11300727
NMDA-evoked calcium transients and currents in the suprachiasmatic nucleus: gating by the circadian system.	2001-04	11298803
Identification of platelet-activating factor as the inflammatory lipid mediator in CCl4-metabolizing rat liver.	2001-04	11290831
Neurotensin excites periaqueductal gray neurons projecting to the rostral ventromedial medulla.	2001-04	11287471
Characterization of cardiac myocyte and tissue beta-adrenergic signal transduction in rats with heart failure.	2001-04	11282076
Acetylcholine increases the free intracellular calcium concentration in podocytes in intact rat glomeruli via muscarinic M(5) receptors.	2001-04	11274228
Role of the endoplasmic reticulum in shaping calcium dynamics in human lens cells.	2001-04	11274079
In vitro and in vivo pharmacological characterization of BIIL 284, a novel and potent leukotriene B(4) receptor antagonist.	2001-04	11259574
Estradiol signaling via sequestrable surface receptors.	2001-04	11250949
Kinetics of activation of a PKC-regulated epithelial calcium channel.	2001-04	11243934
Cyclosporin A increases basal intracellular calcium and calcium responses to endothelin and vasopressin in human coronary myocytes.	2001-03-23	11278005
Interdependent effects of inorganic phosphate and creatine phosphate on sarcoplasmic reticulum Ca2+ regulation in mechanically skinned rat skeletal muscle.	2001-03-15	11251054
Neuronal nicotinic acetylcholine receptor expression by O2A/oligodendrocyte progenitor cells.	2001-03-15	11246229
The anti-anginal drug fendiline increases intracellular Ca(2+) levels in MG63 human osteosarcoma cells.	2001-03-08	11246176
Evidence of calcium influx across the plasma membrane depends upon the initial rise of cytosolic calcium with activation of IP(3) in rat enterocytes by heat-stable enterotoxin of Vibrio cholerae non-O1.	2001-03-01	11257546
Presence and functional significance of neuropeptide and neurotransmitter receptors in subcommissural organ cells.	2001-03-01	11241863
Human IgM anti-GM1 autoantibodies modulate intracellular calcium homeostasis in neuroblastoma cells.	2001-03-01	11240034
Acetylcholine induces cytosolic Ca2+ mobilization in isolated distal colonic crypts from normal and cystic fibrosis mice.	2001-03	11291752
HCO(3)(-) ions modify the role of PKC isoforms in the modulation of rat mast cell functions.	2001-03	11282456
Nutritional lipid emulsions modulate cellular signaling and activation of human neutrophils.	2001-03	11254755
Mechanism of CGRP-induced relaxation in rat intramural coronary arteries.	2001-03	11250874
Cell-cell adhesion in human fibroblasts requires calcium signaling.	2001-03	11228159
Effects of gender on intracellular.	2001-02	11294254
Effects of long-term acidification of extracellular pH on ATP-induced calcium mobilization in rabbit lens epithelial cells.	2001-02	11281999
Human hepatic stellate cells secrete adrenomedullin: potential autocrine factor in the regulation of cell contractility.	2001-02	11281550
Platelet shape change evoked by selective activation of P2X1 purinoceptors with alpha,beta-methylene ATP.	2001-02	11246552
Oxidized-LDL enhances coronary vasoconstriction by increasing the activity of protein kinase C isoforms alpha and epsilon.	2001-02	11230335
Endothelin-1 enhances eicosanoids-induced coronary smooth muscle contraction by activating specific protein kinase C isoforms.	2001-02	11230325
Rise in free intracellular calcium in HeLa cells infected with aggregative Klebsiella pneumoniae strains isolated from cases of diarrhoea.	2001-01	11280164
Effect of cyclosporin A on nitric oxide production in cultured LLC-PK1 cells.	2001-01	11256528
Maitotoxin-induced membrane blebbing and cell death in bovine aortic endothelial cells.	2001	11231888

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:22:17 GMT 2025` Edited by `admin` on `Mon Mar 31 21:22:17 GMT 2025`
Record UNII	TSN3DL106G
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

5-OXAZOLECARBOXYLIC ACID, 2-(6-(BIS(CARBOXYMETHYL)AMINO)-5-(2-(2-(BIS(CARBOXYMETHYL)AMINO)-5-METHYLPHENOXY)ETHOXY)-2-BENZOFURANYL)-

Preferred Name

English

FURA-2

Common Name

English

2-(6-(BIS(CARBOXYMETHYL)AMINO)-5-(2-(2-(BIS(CARBOXYMETHYL)AMINO)-5-METHYLPHENOXY)ETHOXY)-2-BENZOFURANYL)-5-OXAZOLECARBOXYLIC ACID

Systematic Name

English

FURA-2 [MI]

Common Name

English

Code System Code Type Description

FDA UNII

TSN3DL106G