FOSALVUDINE TIDOXIL

Details

Stereochemistry	EPIMERIC
Molecular Formula	C35H64FN2O8PS
Molecular Weight	722.928
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCCCCCCCCCSCC(COP(O)(=O)OC[C@H]1O[C@H](C[C@@H]1F)N2C=C(C)C(=O)NC2=O)OCCCCCCCCCC

InChI

InChIKey=JHXLLEDIXXOJQD-WELGVCPWSA-N

InChI=1S/C35H64FN2O8PS/c1-4-6-8-10-12-14-15-17-19-21-23-48-28-30(43-22-20-18-16-13-11-9-7-5-2)26-44-47(41,42)45-27-32-31(36)24-33(46-32)38-25-29(3)34(39)37-35(38)40/h25,30-33H,4-24,26-28H2,1-3H3,(H,41,42)(H,37,39,40)/t30?,31-,32+,33+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C35H64FN2O8PS
Molecular Weight	722.928
Charge	0
Count

Stereochemistry	EPIMERIC
Additional Stereochemistry	No
Defined Stereocenters	3 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/19433557 | https://www.thepharmaletter.com/article/heidelberg-s-fosalvudine-to-enter-ph-ii

Heidelberg Pharma Research developed fosalvudine tidoxil, a prodrug derived from the nucleoside reverse transcriptase inhibitor alovudine, for the treatment of HIV infections. This drug had reached phase II clinical trials before its development was discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed

Substance Class	Chemical Created by `admin` on `Sat Dec 16 05:40:37 UTC 2023` Edited by `admin` on `Sat Dec 16 05:40:37 UTC 2023`
Record UNII	TR856337M2
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FOSALVUDINE TIDOXIL

Official Name

English

fosalvudine tidoxil [INN]

Common Name

English

5'-THYMIDYLIC ACID, 3'-DEOXY-3'-FLUORO-, MONO(2-(DECYLOXY)-3-(DODECYLTHIO)PROPYL) ESTER

Common Name

English

(2RS)-2-(DECYLOXY)-3-((DODECYL)SULFANYL)PROPYL ((2R,3S,5R)-3-FLUORO-5-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)TETRAHYDROFURAN-2-YL)METHYL HYDROGEN PHOSPHATE

Systematic Name

English

Code System Code Type Description

EPA CompTox

DTXSID10227221