INTERFERON ALPHA/BETA RECEPTOR 2

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 17:58:34 GMT 2025` Edited by `admin` on `Tue Apr 01 17:58:34 GMT 2025`
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	TP3WG3U0B5
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

INTERFERON ALPHA/BETA RECEPTOR 2

Common Name

English

IFN-R-2

Preferred Name

English

IFNARB

Common Name

English

IFNABR

Common Name

English

Code System Code Type Description

UNIPROT

P48551

Created by admin on Tue Apr 01 17:58:34 GMT 2025 , Edited by admin on Tue Apr 01 17:58:34 GMT 2025

PRIMARY

FDA UNII

TP3WG3U0B5

Created by admin on Tue Apr 01 17:58:34 GMT 2025 , Edited by admin on Tue Apr 01 17:58:34 GMT 2025

PRIMARY

From	To
1_13	1_96
1_59	1_67
1_181	1_201

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_32
N	1_61
N	1_90
N	1_162
N	1_166

Related Record Type Details


					G8RGG88B68

PEGINTERFERON ALFA-2B

AGONIST -> TARGET


					H9CK7SS0T6

Acinterferon alfa

AGONIST -> TARGET

Comments:

Nova exhibited a higher binding affinity for IFN receptor 2 (IFNR2) than rhIFN-?2b, which is one of the possible reasons accounting for its stronger actions against tumor cells compared with rhIFN-?2b.

Interaction Type:

AGONIST

Qualification:

Kd

Amount:


					N7FO1V18PR

ERAMKAFUSP ALFA

ACTIVATOR -> TARGET


					Q46947FE7K

PEGINTERFERON ALFA-2A

AGONIST -> TARGET


					695DKH33EI

NYLIDRIN

AGONIST -> TARGET

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_311] [1_486]				TYROSINE O-PHOSPHATE	2R86C98KDX
AMINO ACID SUBSTITUTION	[1_441]				DEXFOSFOSERINE	VI4F0K069V

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT	CHEMICAL