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Details

Stereochemistry RACEMIC
Molecular Formula C21H20FN3O3
Molecular Weight 381.4002
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PK-14105

SMILES

CCC(C)N(C)C(=O)C1=NC(=C2C=CC=CC2=C1)C3=C(F)C=CC(=C3)[N+]([O-])=O

InChI

InChIKey=GXXKDYZSBGOJQN-UHFFFAOYSA-N
InChI=1S/C21H20FN3O3/c1-4-13(2)24(3)21(26)19-11-14-7-5-6-8-16(14)20(23-19)17-12-15(25(27)28)9-10-18(17)22/h5-13H,4H2,1-3H3

HIDE SMILES / InChI

Molecular Formula C21H20FN3O3
Molecular Weight 381.4002
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
PubMed

PubMed

TitleDatePubMed
Affinity labeling of membrane receptors using tissue-penetrating radiations.
2013
Pharmacological characterization of an 18-kDa protein associated with the peripheral-type benzodiazepine receptor in salivary glands.
2000-02
Two cellular and subcellular locations for the peripheral-type benzodiazepine receptor in rat liver.
1996-05-17
Photoaffinity labeling of peripheral benzodiazepine receptors in R-3327 Dunning prostatic tumors.
1996-04-26
Identification and purification of a 10-kilodalton protein associated with mitochondrial benzodiazepine receptors.
1995-09-01
The role of cyclic nucleotides in the action of peripheral-type benzodiazepine receptor ligands in rat aorta.
1994-12
The peripheral-type benzodiazepine receptor is present in astrocytes but is not a primary site of action for convulsants/anticonvulsants.
1994-02
AHN 683: a fluorescent ligand for peripheral-type benzodiazepine receptors.
1992-08
Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier.
1992-04-15
The mitochondrial benzodiazepine receptor: evidence for association with the voltage-dependent anion channel (VDAC).
1992-02
Expression and pharmacological characterization of the human peripheral-type benzodiazepine receptor in yeast.
1991-12-12
Identification of a 17-kDa protein associated with the peripheral-type benzodiazepine receptor in vascular and other smooth muscle types.
1991-08
Cloning and expression of a pharmacologically unique bovine peripheral-type benzodiazepine receptor isoquinoline binding protein.
1991-07-25
The bovine peripheral-type benzodiazepine receptor: a receptor with low affinity for benzodiazepines.
1991
Substance Class Chemical
Created
by admin
on Mon Mar 31 22:52:45 GMT 2025
Edited
by admin
on Mon Mar 31 22:52:45 GMT 2025
Record UNII
TOL0WGC9VU
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PK-14105
Common Name English
3-ISOQUINOLINECARBOXAMIDE, 1-(2-FLUORO-5-NITROPHENYL)-N-METHYL-N-(1-METHYLPROPYL)-
Preferred Name English
Code System Code Type Description
FDA UNII
TOL0WGC9VU
Created by admin on Mon Mar 31 22:52:45 GMT 2025 , Edited by admin on Mon Mar 31 22:52:45 GMT 2025
PRIMARY
EPA CompTox
DTXSID80910274
Created by admin on Mon Mar 31 22:52:45 GMT 2025 , Edited by admin on Mon Mar 31 22:52:45 GMT 2025
PRIMARY
PUBCHEM
122277
Created by admin on Mon Mar 31 22:52:45 GMT 2025 , Edited by admin on Mon Mar 31 22:52:45 GMT 2025
PRIMARY
CAS
107257-28-3
Created by admin on Mon Mar 31 22:52:45 GMT 2025 , Edited by admin on Mon Mar 31 22:52:45 GMT 2025
PRIMARY