PEGCETACOPLAN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 22:56:36 GMT 2025` Edited by `admin` on `Tue Apr 01 22:56:36 GMT 2025`
Protein Type	PEPTIDE
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	TO3JYR3BOU
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

EMPAVELI

Preferred Name

English

PEGCETACOPLAN

Official Name

English

SYFOVRE

Brand Name

English

PEGCETACOPLAN [USAN]

Common Name

English

POLY(OXY-1,2-ETHANEDIYL), .ALPHA.-HYDRO-.OMEGA.-HYDROXY-, 15,15'-DIESTER WITH N-ACETYL-L-ISOLEUCYL-L-CYSTEINYL-L-VALYL-1-METHYL-L-TRYPTOPHYL-L-GLUTAMINYL-L-.ALPHA.-ASPARTYL-L-TRYPTOPHYLGLYCYL-L-ALANYL-L-HISTIDYL-L-ARGINYL-L-CYSTEINYL-L-THREONYL-2-(2-(2-A

Systematic Name

English

pegcetacoplan [INN]

Common Name

English

O,O'-BIS((S2,S12-CYCLO(N-ACETYL-L-ISOLEUCYL-L-CYSTEINYL-L-VALYL-1-METHYL-L-TRYPTOPHYL-L-GLUTAMINYL-L-.ALPHA.-ASPARTYL-L-TRYPTOPHYLGLYCYL-L-ALANYL-L-HISTIDYL-L-ARGINYL-L-CYSTEINYL-L-THREONYL-2-(2-(2-AMINOETHOXY)ETHOXY)ACETYL-L-LYSINAMIDE))-N6.15-CARBONYL)

Systematic Name

English

APL-2

Code

English

Pegcetacoplan [WHO-DD]

Common Name

English

PEGCETACOPLAN [ORANGE BOOK]

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

427614

Created by admin on Tue Apr 01 22:56:36 GMT 2025 , Edited by admin on Tue Apr 01 22:56:36 GMT 2025

FDA ORPHAN DRUG

817321

Created by admin on Tue Apr 01 22:56:36 GMT 2025 , Edited by admin on Tue Apr 01 22:56:36 GMT 2025

FDA ORPHAN DRUG

627018

Created by admin on Tue Apr 01 22:56:36 GMT 2025 , Edited by admin on Tue Apr 01 22:56:36 GMT 2025

FDA ORPHAN DRUG

799620

Created by admin on Tue Apr 01 22:56:36 GMT 2025 , Edited by admin on Tue Apr 01 22:56:36 GMT 2025

FDA ORPHAN DRUG

633418

Created by admin on Tue Apr 01 22:56:36 GMT 2025 , Edited by admin on Tue Apr 01 22:56:36 GMT 2025

Code System Code Type Description

DAILYMED

TO3JYR3BOU

Created by admin on Tue Apr 01 22:56:36 GMT 2025 , Edited by admin on Tue Apr 01 22:56:36 GMT 2025

PRIMARY

USAN

FG-216

Created by admin on Tue Apr 01 22:56:36 GMT 2025 , Edited by admin on Tue Apr 01 22:56:36 GMT 2025

PRIMARY

WIKIPEDIA

Pegcetacoplan

Created by admin on Tue Apr 01 22:56:36 GMT 2025 , Edited by admin on Tue Apr 01 22:56:36 GMT 2025

PRIMARY

INN

10743

Created by admin on Tue Apr 01 22:56:36 GMT 2025 , Edited by admin on Tue Apr 01 22:56:36 GMT 2025

PRIMARY

EVMPD

SUB195466

Created by admin on Tue Apr 01 22:56:36 GMT 2025 , Edited by admin on Tue Apr 01 22:56:36 GMT 2025

PRIMARY

NCI_THESAURUS

C121135

Created by admin on Tue Apr 01 22:56:36 GMT 2025 , Edited by admin on Tue Apr 01 22:56:36 GMT 2025

PRIMARY

SMS_ID

100000181711

Created by admin on Tue Apr 01 22:56:36 GMT 2025 , Edited by admin on Tue Apr 01 22:56:36 GMT 2025

PRIMARY

CAS

2019171-69-6

Created by admin on Tue Apr 01 22:56:36 GMT 2025 , Edited by admin on Tue Apr 01 22:56:36 GMT 2025

PRIMARY

RXCUI

2557372

Created by admin on Tue Apr 01 22:56:36 GMT 2025 , Edited by admin on Tue Apr 01 22:56:36 GMT 2025

PRIMARY

FDA UNII

TO3JYR3BOU

Created by admin on Tue Apr 01 22:56:36 GMT 2025 , Edited by admin on Tue Apr 01 22:56:36 GMT 2025

PRIMARY

From	To
1_2	1_12
2_2	2_12

Related Record Type Details


					UM18T01RY8

TARGET -> INHIBITOR

Comments:

Inhibits C3 activation

Amount:

Related Record Type Details


					TO3JYR3BOU

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_4] [2_4]	SITE_SPECIFIC			N-1-Methyl-L-tryptophan	XD0FY1J13B
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS			N-ACETYLISOLEUCINE	P9CL0Y0BVZ
PEGYLATION	[1_14] [2_14]	C-TERMINUS			PEGCETACOPLAN LYSINE MODIFICATION	P1K5L81WUZ

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL