Anselamimab

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 18:50:28 GMT 2023` Edited by `admin` on `Sat Dec 16 18:50:28 GMT 2023`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Type	COMPLETE
Record UNII	TL94QQ5RTW
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Anselamimab

Official Name

English

ANSELAMIMAB [USAN]

Common Name

English

IMMUNOGLOBULIN G1, ANTI-(HUMAN AMYLOID FIBRIL) (HUMAN-MUS MUSCULUS MONOCLONAL CAEL-101 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS MONOCLONAL CAEL-101 .KAPPA.-CHAIN, DIMER

Common Name

English

CAEL-101

Code

English

11-1F4

Common Name

English

Chimeric fibril reactive monoclonal antibody 11-1F4

Common Name

English

anselamimab [INN]

Common Name

English

IMMUNOGLOBULIN G1-KAPPA, ANTI-(HOMO SAPIENS IMMUNOGLOBULIN LIGHT CHAIN AMYLOID (AL) FIBRILS), CHIMERIC MONOCLONAL ANTIBODY (GAMMA1 HEAVY CHAIN CHIMERIC (1-441) (MUS MUSCULUS VH (IGHV2-3*01 (92.6%)-(IGHD)-IGHJ4*01 (92.9%), CDR-IMGT (8.7.5) (26-33.51-57.96

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

290309

Created by admin on Sat Dec 16 18:50:28 GMT 2023 , Edited by admin on Sat Dec 16 18:50:28 GMT 2023

FDA ORPHAN DRUG

293709

Created by admin on Sat Dec 16 18:50:28 GMT 2023 , Edited by admin on Sat Dec 16 18:50:28 GMT 2023

Code System Code Type Description

FDA UNII

TL94QQ5RTW

Created by admin on Sat Dec 16 18:50:28 GMT 2023 , Edited by admin on Sat Dec 16 18:50:28 GMT 2023

PRIMARY

USAN

LM-147

Created by admin on Sat Dec 16 18:50:28 GMT 2023 , Edited by admin on Sat Dec 16 18:50:28 GMT 2023

PRIMARY

NCI_THESAURUS

C117241

Created by admin on Sat Dec 16 18:50:28 GMT 2023 , Edited by admin on Sat Dec 16 18:50:28 GMT 2023

PRIMARY

CAS

2414866-63-8

Created by admin on Sat Dec 16 18:50:28 GMT 2023 , Edited by admin on Sat Dec 16 18:50:28 GMT 2023

PRIMARY

INN

11703

Created by admin on Sat Dec 16 18:50:28 GMT 2023 , Edited by admin on Sat Dec 16 18:50:28 GMT 2023

PRIMARY

From	To
1_22	1_95
2_22	2_95
2_138	2_194
2_214	4_219
2_255	2_315
1_138	1_194
2_361	2_419
3_23	3_93
3_139	3_199
4_23	4_93
4_139	4_199
1_214	3_219
1_220	2_220
1_223	2_223
1_255	1_315
1_361	1_419

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_291
N	2_291

Related Record Type Details


					9D9YY8W7VX

Amyloid fibrils IgG light chain

TARGET->INHIBITOR OF AGGREGATION

Comments:

Binds and leads to phagocytosis of fibrils.

Amount:

Related Record Type Details


					TL94QQ5RTW

ACTIVE MOIETY

Comments:

elimination of immunoglobulin light chain amyloid deposits

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL