Zolbetuximab

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 01:43:10 GMT 2025` Edited by `admin` on `Wed Apr 02 01:43:10 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	TF5MPQ8WGY
Record Status	`Validated (UNII)`
Record Version

Download

Related Record	Type

Name

Type

Language

IMAB-362

Preferred Name

English

Zolbetuximab

Official Name

English

Zolbetuximab [WHO-DD]

Common Name

English

ZOLBETUXIMAB [USAN]

Common Name

English

CLAUDIXIMAB

Common Name

English

Immunoglobulin G1, anti-(human claudin-18.2) (human-Mus musculus monoclonal IMAB362 heavy chain), disulfide with human-Mus musculus monoclonal IMAB362 ?-chain, dimer

Common Name

English

Immunoglobulin G1-kappa, anti-[Homo sapiens CLDN18 (claudin 18, claudin-18, SFTPJ, surfactant associated protein J) isoform 2, extracellular domain 1 (EC1)], chimeric monoclonal antibody; gamma1 heavy chain (1-448) [Mus musculus VH (IGHV1-61*01 (92.90%)

Common Name

English

zolbetuximab [INN]

Common Name

English

IMAB362

Code

English

ZOLBETUXIMAB [JAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C20401

Created by admin on Wed Apr 02 01:43:10 GMT 2025 , Edited by admin on Wed Apr 02 01:43:10 GMT 2025

NCI_THESAURUS

C129822

Created by admin on Wed Apr 02 01:43:10 GMT 2025 , Edited by admin on Wed Apr 02 01:43:10 GMT 2025

FDA ORPHAN DRUG

383312

Created by admin on Wed Apr 02 01:43:10 GMT 2025 , Edited by admin on Wed Apr 02 01:43:10 GMT 2025

Code System Code Type Description

CAS

1496553-00-4

Created by admin on Wed Apr 02 01:43:10 GMT 2025 , Edited by admin on Wed Apr 02 01:43:10 GMT 2025

PRIMARY

INN

10473

Created by admin on Wed Apr 02 01:43:10 GMT 2025 , Edited by admin on Wed Apr 02 01:43:10 GMT 2025

PRIMARY

DRUG BANK

DB15118

Created by admin on Wed Apr 02 01:43:10 GMT 2025 , Edited by admin on Wed Apr 02 01:43:10 GMT 2025

PRIMARY

WIKIPEDIA

Zolbetuximab

Created by admin on Wed Apr 02 01:43:10 GMT 2025 , Edited by admin on Wed Apr 02 01:43:10 GMT 2025

PRIMARY

NCI_THESAURUS

C85475

Created by admin on Wed Apr 02 01:43:10 GMT 2025 , Edited by admin on Wed Apr 02 01:43:10 GMT 2025

PRIMARY

USAN

KL-138

Created by admin on Wed Apr 02 01:43:10 GMT 2025 , Edited by admin on Wed Apr 02 01:43:10 GMT 2025

PRIMARY

FDA UNII

TF5MPQ8WGY

Created by admin on Wed Apr 02 01:43:10 GMT 2025 , Edited by admin on Wed Apr 02 01:43:10 GMT 2025

PRIMARY

SMS_ID

100000175835

Created by admin on Wed Apr 02 01:43:10 GMT 2025 , Edited by admin on Wed Apr 02 01:43:10 GMT 2025

PRIMARY

CHEMBL

CHEMBL2109427

Created by admin on Wed Apr 02 01:43:10 GMT 2025 , Edited by admin on Wed Apr 02 01:43:10 GMT 2025

PRIMARY

From	To
4_140	4_200
3_140	3_200
4_23	4_94
3_23	3_94
2_368	2_426
1_368	1_426
2_262	2_322
1_262	1_322
1_230	2_230
1_227	2_227
2_221	4_220
1_221	3_220
2_145	2_201
1_145	1_201
2_22	2_96
1_22	1_96

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_298
N	2_298

Related Record Type Details

Zolbetuximab-CLZB

SUB_CONCEPT->SUBSTANCE

Amount:


					O86SW5D7BQ

CLAUDIN 18 SPLICE VARIANT 2

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					TF5MPQ8WGY

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL