Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C16H9NO2 |
| Molecular Weight | 247.2482 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[O-][N+](=O)C1=C2C=CC3=C4C(C=CC(C=C1)=C24)=CC=C3
InChI
InChIKey=ALRLPDGCPYIVHP-UHFFFAOYSA-N
InChI=1S/C16H9NO2/c18-17(19)14-9-7-12-5-4-10-2-1-3-11-6-8-13(14)16(12)15(10)11/h1-9H
| Molecular Formula | C16H9NO2 |
| Molecular Weight | 247.2482 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Low levels of the air pollutant 1-nitropyrene induce DNA damage, increased levels of reactive oxygen species and endoplasmic reticulum stress in human endothelial cells. | 2009-07-28 |
|
| Determination of 1-nitropyrene in low volume ambient air samples by high-performance liquid chromatography with fluorescence detection. | 2009-05-22 |
|
| Cytokine and chemokine expression patterns in lung epithelial cells exposed to components characteristic of particulate air pollution. | 2009-05-02 |
|
| Mechanistic studies of the bypass of a bulky single-base lesion catalyzed by a Y-family DNA polymerase. | 2009-03-06 |
|
| Synthesis of oligonucleotides containing 2'-deoxyguanosine adducts of nitropyrenes. | 2009-02 |
|
| Induction of pro-inflammatory signals by 1-nitropyrene in cultured BEAS-2B cells. | 2009-01-30 |
|
| Bacterial degradation of aromatic compounds. | 2009-01 |
|
| Quantification of 1-aminopyrene in human urine after a controlled exposure to diesel exhaust. | 2009-01 |
|
| Pharmacologic profiling of human and rat cytochrome P450 1A1 and 1A2 induction and competition. | 2008-12 |
|
| 1-Nitropyrene efficiently induces mitotic recombination in Saccharomyces cerevisiae. | 2008-11 |
|
| Photophysics and photochemistry of 1-nitropyrene. | 2008-10-16 |
|
| Tissue-specific metabolic activation and mutagenicity of 3-nitrobenzanthrone in MutaMouse. | 2008-10 |
|
| Mutation spectra induced by 1-nitropyrene 4,5-oxide and 1-nitropyrene 9,10-oxide in the supF gene of human XP-A fibroblasts. | 2008-08-31 |
|
| Mutational specificity of gamma-radiation-induced guanine-thymine and thymine-guanine intrastrand cross-links in mammalian cells and translesion synthesis past the guanine-thymine lesion by human DNA polymerase eta. | 2008-08-05 |
|
| Environmental photochemistry of nitro-PAHs: direct observation of ultrafast intersystem crossing in 1-nitropyrene. | 2008-07-17 |
|
| 1-Nitropyrene (1-NP) induces apoptosis and apparently a non-apoptotic programmed cell death (paraptosis) in Hepa1c1c7 cells. | 2008-07-15 |
|
| ECVAM retrospective validation of in vitro micronucleus test (MNT). | 2008-07 |
|
| Hibiscus sabdariffa L. extracts inhibit the mutagenicity in microsuspension assay and the proliferation of HeLa cells. | 2008-06 |
|
| Vapor pressures and thermodynamics of oxygen-containing polycyclic aromatic hydrocarbons measured using Knudsen effusion. | 2008-06 |
|
| Excited-state dynamics of nitroperylene in solution: solvent and excitation wavelength dependence. | 2008-05-01 |
|
| Screening of 397 chemicals and development of a quantitative structure--activity relationship model for androgen receptor antagonism. | 2008-04 |
|
| Aldo-keto reductase 1C2 is essential for 1-nitropyrene's but not for benzo[a]pyrene's induction of p53 phosphorylation and apoptosis. | 2008-02-28 |
|
| Polycyclic aromatic hydrocarbons aggravate antigen-induced nasal blockage in experimental allergic rhinitis. | 2007-11 |
|
| Mutagenicity of the 1-nitropyrene-DNA adduct N-(deoxyguanosin-8-yl)-1-aminopyrene in mammalian cells. | 2007-11 |
|
| Determination of nitro-polycyclic aromatic hydrocarbons in atmospheric aerosols using HPLC fluorescence with a post-column derivatisation technique. | 2007-11 |
|
| Analysis of 1-nitropyrene in air particulate matter standard reference materials by using two-dimensional high performance liquid chromatography with online reduction and tandem mass spectrometry detection. | 2007-10-12 |
|
| Polycyclic aromatic hydrocarbons (PAHs), nitrated PAHs and oxygenated PAHs in ambient air of the Marseilles area (South of France): concentrations and sources. | 2007-10-01 |
|
| Enhanced mutagenesis of Salmonella tester strains due to deletion of genes other than uvrB. | 2007-10 |
|
| Optimization of an improved analytical method for the determination of 1-nitropyrene in milligram diesel soot samples by high-performance liquid chromatography-mass spectrometry. | 2007-09-07 |
|
| The cda GenoTox assay: a new and sensitive method for detection of environmental genotoxins, including nitroarenes and aromatic amines. | 2007-07-28 |
|
| Identification and quantification of 1-nitropyrene metabolites in human urine as a proposed biomarker for exposure to diesel exhaust. | 2007-07 |
|
| Effects of nitrated-polycyclic aromatic hydrocarbons and diesel exhaust particle extracts on cell signalling related to apoptosis: possible implications for their mutagenic and carcinogenic effects. | 2007-03-07 |
|
| Singlet excited-state dynamics of nitropolycyclic aromatic hydrocarbons: direct measurements by femtosecond fluorescence up-conversion. | 2007-02-01 |
|
| Mutagenic activities and physicochemical properties of selected nitrobenzanthrones. | 2006-11 |
|
| Nitrocompound activation by cell-free extracts of nitroreductase-proficient Salmonella typhimurium strains. | 2006-11 |
|
| Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods. | 2006-11 |
|
| In vitro anti-mutagenic effect of magnolol against direct and indirect mutagens. | 2006-10-10 |
|
| The potential risks of nanomaterials: a review carried out for ECETOC. | 2006-08-14 |
|
| An in vivo model for testing genotoxicity of environmental fibre-associated nitroarenes. | 2006-08-12 |
|
| Gas-phase ambient air contaminants exhibit significant dioxin-like and estrogen-like activity in vitro. | 2006-05 |
|
| Suppressive effect of 1-nitropyrene on benzo[a]pyrene-induced CYP1A1 protein expression in HepG2 cells. | 2006-03-01 |
|
| Determination of 1-nitropyrene metabolites by high-performance liquid chromatography with chemiluminescence detection. | 2006-02-24 |
|
| [In vivo mutagenicity of the carcinogenic 1-nitropyrene. A model of a potential asbestos exposure]. | 2006 |
|
| Detection of initiating as well as promoting activity of chemicals by a novel cell transformation assay using v-Ha-ras-transfected BALB/c 3T3 cells (Bhas 42 cells). | 2005-12-07 |
|
| Involvement of alveolar macrophages in the formation of 8-oxodeoxyguanosine associated with exogenous particles in human lungs. | 2005-10 |
|
| Assessment of 3-nitrobenzanthrone reductase activity in mammalian tissues by normal-phase HPLC with fluorescence detection. | 2005-09-25 |
|
| Involvement of molybdenum hydroxylases in reductive metabolism of nitro polycyclic aromatic hydrocarbons in mammalian skin. | 2005-09 |
|
| The antimutagenic activity of Lavandula angustifolia (lavender) essential oil in the bacterial reverse mutation assay. | 2005-09 |
|
| The effects of 1-nitropyrene on oxidative DNA damage and expression of DNA repair enzymes. | 2005-05 |
|
| Carcinogenicity of dinitropyrenes in the weanling female CD rat. | 1991-07 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 21:29:45 GMT 2025
by
admin
on
Mon Mar 31 21:29:45 GMT 2025
|
| Record UNII |
TD1665I8Q4
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
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Systematic Name | English | ||
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Preferred Name | English | ||
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Systematic Name | English | ||
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Systematic Name | English | ||
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Systematic Name | English | ||
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Common Name | English | ||
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Common Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
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NCI_THESAURUS |
C45182
Created by
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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6980
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1-NITROPYRENE
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5522-43-0
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C032668
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226-868-2
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34107
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TD1665I8Q4
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PRIMARY | |||
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C29781
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DTXSID6020983
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81340
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21694
Created by
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PRIMARY |
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