Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C15H18O4 |
Molecular Weight | 262.301 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 5 / 5 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@]12[C@@H](C)C(=O)O[C@]1([H])[C@@]3([H])C(C)=CC(=O)C3=C(C)C[C@@H]2O
InChI
InChIKey=YMUOZXZDDBRJEP-SSGZPDKPSA-N
InChI=1S/C15H18O4/c1-6-4-10(17)13-8(3)15(18)19-14(13)12-7(2)5-9(16)11(6)12/h5,8,10,12-14,17H,4H2,1-3H3/t8-,10+,12+,13-,14-/m1/s1
Molecular Formula | C15H18O4 |
Molecular Weight | 262.301 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 4 / 5 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/8814460
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8814460
Hydroxyachillin, a sesquiterpene lactone, and the main component isolated from aerial parts of Tanacetum microphyllum DC, the last is used in folk medicine as an anti-inflammatory and anti-ulcer agent. Hydroxyachillin was also the effective anti-inflammatory agent in the mouse model of ear edema. Besides, the inhibition of protein kinase C may be one of the mechanisms of hydroxyachillin's effect.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL2093867 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8814460 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Unknown Approved UseUnknown |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8073088
Carrageenan-induced edema in mice: hydroxyachillin (40 mg/kg) were administered p.o. 1 h before the carrageanan injection.
Route of Administration:
Oral
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:39:58 GMT 2023
by
admin
on
Sat Dec 16 08:39:58 GMT 2023
|
Record UNII |
TB9KU0WDEE
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English |
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
TB9KU0WDEE
Created by
admin on Sat Dec 16 08:39:58 GMT 2023 , Edited by admin on Sat Dec 16 08:39:58 GMT 2023
|
PRIMARY | |||
|
35879-92-6
Created by
admin on Sat Dec 16 08:39:58 GMT 2023 , Edited by admin on Sat Dec 16 08:39:58 GMT 2023
|
PRIMARY | |||
|
10038339
Created by
admin on Sat Dec 16 08:39:58 GMT 2023 , Edited by admin on Sat Dec 16 08:39:58 GMT 2023
|
PRIMARY |