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Details

Stereochemistry ABSOLUTE
Molecular Formula C15H18O4
Molecular Weight 262.301
Optical Activity UNSPECIFIED
Defined Stereocenters 5 / 5
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of HYDROXYACHILLIN

SMILES

C[C@@H]1[C@H]2[C@H](OC1=O)[C@H]3C(C)=CC(=O)C3=C(C)C[C@@H]2O

InChI

InChIKey=YMUOZXZDDBRJEP-SSGZPDKPSA-N
InChI=1S/C15H18O4/c1-6-4-10(17)13-8(3)15(18)19-14(13)12-7(2)5-9(16)11(6)12/h5,8,10,12-14,17H,4H2,1-3H3/t8-,10+,12+,13-,14-/m1/s1

HIDE SMILES / InChI

Molecular Formula C15H18O4
Molecular Weight 262.301
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 5 / 5
E/Z Centers 0
Optical Activity UNSPECIFIED

Hydroxyachillin, a sesquiterpene lactone, and the main component isolated from aerial parts of Tanacetum microphyllum DC, the last is used in folk medicine as an anti-inflammatory and anti-ulcer agent. Hydroxyachillin was also the effective anti-inflammatory agent in the mouse model of ear edema. Besides, the inhibition of protein kinase C may be one of the mechanisms of hydroxyachillin's effect.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Inhibition by hydroxyachillin, sesquiterpene lactone from Tanacetum microphyllum, of PMA-induced mouse ear oedema.
1996-06
Anti-inflammatory activity of hydroxyachillin, a sesquiterpene lactone from Tanacetum microphyllum.
1994-06

Sample Use Guides

Carrageenan-induced edema in mice: hydroxyachillin (40 mg/kg) were administered p.o. 1 h before the carrageanan injection.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Mon Mar 31 22:15:00 GMT 2025
Edited
by admin
on Mon Mar 31 22:15:00 GMT 2025
Record UNII
TB9KU0WDEE
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
HYDROXYACHILLIN
Common Name English
8.ALPHA.-HYDROXYACHILLIN
Preferred Name English
GROSSMIZIN
Common Name English
GROSSMISIN
Common Name English
ACHILLIN, HYDROXY-
Common Name English
AZULENO(4,5-B)FURAN-2,7-DIONE, 3,3A,4,5,9A,9B-HEXAHYDRO-4-HYDROXY-3,6,9-TRIMETHYL-, (3R,3AR,4S,9AS,9BR)-
Systematic Name English
Code System Code Type Description
FDA UNII
TB9KU0WDEE
Created by admin on Mon Mar 31 22:15:00 GMT 2025 , Edited by admin on Mon Mar 31 22:15:00 GMT 2025
PRIMARY
CAS
35879-92-6
Created by admin on Mon Mar 31 22:15:00 GMT 2025 , Edited by admin on Mon Mar 31 22:15:00 GMT 2025
PRIMARY
PUBCHEM
10038339
Created by admin on Mon Mar 31 22:15:00 GMT 2025 , Edited by admin on Mon Mar 31 22:15:00 GMT 2025
PRIMARY