Nuvustotug

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 12:39:05 GMT 2025` Edited by `admin` on `Wed Apr 02 12:39:05 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1\|KAPPA
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	TA3CUZ8Y5M
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

H-gamma1 heavy chain Homo sapiens (1-452) [VH (Homo sapiens IGHV3-23*01 (99.0%) -(IGHD) -IGHJ3*02 (100%), CDRIMGT [8.8.15] (26-33.51-58.97-111)) (1-122) -Homo sapiens IGHG1*03v (100%) G1m3>G1m17, nG1m1 CH1 K120, CH3 E12, M14 (CH1 R120>K (219) (123-220),

Preferred Name

English

Nuvustotug

Official Name

English

immunoglobulin G1-kappa, anti-[Homo sapiens TNFRSF4 (tumor necrosis factor receptor (TNFR) superfamily member 4, OX40, CD134)], Homo sapiens monoclonal antibody

Common Name

English

Immunoglobulin G1, anti-(human CD134 antigen) (human monoclonal HFB301001 ?1-chain), disulfide with human monoclonal HFB301001 ?-chain, dimer

Common Name

English

nuvustotug [INN]

Common Name

English

Code System Code Type Description

INN

13091

Created by admin on Wed Apr 02 12:39:05 GMT 2025 , Edited by admin on Wed Apr 02 12:39:05 GMT 2025

PRIMARY

CAS

2916519-49-6

Created by admin on Wed Apr 02 12:39:05 GMT 2025 , Edited by admin on Wed Apr 02 12:39:05 GMT 2025

PRIMARY

SMS_ID

300000038771

Created by admin on Wed Apr 02 12:39:05 GMT 2025 , Edited by admin on Wed Apr 02 12:39:05 GMT 2025

PRIMARY

FDA UNII

TA3CUZ8Y5M

Created by admin on Wed Apr 02 12:39:05 GMT 2025 , Edited by admin on Wed Apr 02 12:39:05 GMT 2025

PRIMARY

NCI_THESAURUS

C187289

Created by admin on Wed Apr 02 12:39:05 GMT 2025 , Edited by admin on Wed Apr 02 12:39:05 GMT 2025

PRIMARY

From	To
1_22	1_96
2_22	2_96
2_149	2_205
2_225	4_214
2_266	2_326
1_149	1_205
2_372	2_430
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194
1_225	3_214
1_231	2_231
1_234	2_234
1_266	1_326
1_372	1_430

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_302
N	2_302

Related Record Type Details


					115VXA358P

TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 4

TARGET -> AGONIST

Comments:

OX40, also known as cluster of differentiation (CD) 134 and tumor necrosis factor (TNF) receptor super family member 4 (TNFRSF4), is a receptor expressed primarily on activated CD4+ and CD8+ T cells. Receptor stimulation by the endogenous OX40 ligand (OX40L) or agonist OX40 antibodies can induce a co-stimulatory signal on T cell

Amount:

Related Record Type Details


					TA3CUZ8Y5M

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL