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Details

Stereochemistry ABSOLUTE
Molecular Formula C21H21FN4O3.3H2O
Molecular Weight 450.4607
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Pradofloxacin trihydrate

SMILES

O.O.O.[H][C@]12CN(C[C@@]1([H])NCCC2)C3=C(C#N)C4=C(C=C3F)C(=O)C(=CN4C5CC5)C(O)=O

InChI

InChIKey=OTPLAFVGCAMVAC-DEWAGMQLSA-N
InChI=1S/C21H21FN4O3.3H2O/c22-16-6-13-18(26(12-3-4-12)9-15(20(13)27)21(28)29)14(7-23)19(16)25-8-11-2-1-5-24-17(11)10-25;;;/h6,9,11-12,17,24H,1-5,8,10H2,(H,28,29);3*1H2/t11-,17+;;;/m0.../s1

HIDE SMILES / InChI

Molecular Formula H2O
Molecular Weight 18.0153
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C21H21FN4O3
Molecular Weight 396.4148
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Pradofloxacin (trade name Veraflox) is a 3rd generation enhanced spectrum veterinary antibiotic of the fluoroquinolone class. It was developed by Bayer HealthCare AG, Animal Health GmbH, and received approval from the European Commission in April 2011 for prescription-only use in veterinary medicine for the treatment of bacterial infections in dogs and cats. The primary mode of action of fluoroquinolones involves interaction with enzymes essential for major DNA functions such as replication, transcription, and recombination. The primary targets for Pradofloxacin are the bacterial DNA gyrase and topoisomerase IV enzymes. Reversible association between Pradofloxacin and DNA gyrase or DNA topoisomerase IV in the target bacteria results in inhibition of these enzymes and rapid death of the bacterial cell. The rapidity and extent of bacterial killing are directly proportional to the drug concentration.

Originator

Curator's Comment: # Bayer Aktiengesellschaft

Approval Year

PubMed

PubMed

TitleDatePubMed
Use of pradofloxacin to treat experimentally induced Mycoplasma hemofelis infection in cats.
2009 Jan
Patents

Sample Use Guides

Administer 3.0 mg/kg bodyweight of pradofloxacin once daily.
Route of Administration: Oral
The MIC of pradofloxacinc was determined by broth microdilution according to Clinical and Laboratory Standards Institute (CLSI) standards,6 within the concentration range 0.008–16 μg/mL. The MICs of enrofloxacin and ciprofloxacin were determined using commercial stripsd on Mueller–Hinton 2 agar inoculated with a bacterial suspension (density of 0.5 McFarland) and incubated for 24 h at 35°C. The reference strain S. aureus ATCC 25923 was used as a quality control for MIC determination with the commercial strips, according to the manufacturer’s instructions.
Substance Class Chemical
Created
by admin
on Sat Dec 16 19:50:45 GMT 2023
Edited
by admin
on Sat Dec 16 19:50:45 GMT 2023
Record UNII
T9J58ERF3L
Record Status Validated (UNII)
Record Version
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Name Type Language
Pradofloxacin trihydrate
Common Name English
3-Quinolinecarboxylic acid, 8-cyano-1-cyclopropyl-6-fluoro-1,4-dihydro-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-, trihydrate
Systematic Name English
3-Quinolinecarboxylic acid, 8-cyano-1-cyclopropyl-6-fluoro-1,4-dihydro-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-, hydrate (1:3)
Systematic Name English
Code System Code Type Description
PUBCHEM
67315146
Created by admin on Sat Dec 16 19:50:45 GMT 2023 , Edited by admin on Sat Dec 16 19:50:45 GMT 2023
PRIMARY
FDA UNII
T9J58ERF3L
Created by admin on Sat Dec 16 19:50:45 GMT 2023 , Edited by admin on Sat Dec 16 19:50:45 GMT 2023
PRIMARY
CAS
866760-50-1
Created by admin on Sat Dec 16 19:50:45 GMT 2023 , Edited by admin on Sat Dec 16 19:50:45 GMT 2023
PRIMARY
Related Record Type Details
ANHYDROUS->SOLVATE
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY