Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C21H21FN4O3.3H2O |
| Molecular Weight | 450.4607 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O.O.O.[H][C@]12CN(C[C@@]1([H])NCCC2)C3=C(C#N)C4=C(C=C3F)C(=O)C(=CN4C5CC5)C(O)=O
InChI
InChIKey=OTPLAFVGCAMVAC-DEWAGMQLSA-N
InChI=1S/C21H21FN4O3.3H2O/c22-16-6-13-18(26(12-3-4-12)9-15(20(13)27)21(28)29)14(7-23)19(16)25-8-11-2-1-5-24-17(11)10-25;;;/h6,9,11-12,17,24H,1-5,8,10H2,(H,28,29);3*1H2/t11-,17+;;;/m0.../s1
| Molecular Formula | H2O |
| Molecular Weight | 18.0153 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C21H21FN4O3 |
| Molecular Weight | 396.4148 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Pradofloxacin (trade name Veraflox) is a 3rd generation enhanced spectrum veterinary antibiotic of the fluoroquinolone class. It was developed by Bayer HealthCare AG, Animal Health GmbH, and received approval from the European Commission in April 2011 for prescription-only use in veterinary medicine for the treatment of bacterial infections in dogs and cats. The primary mode of action of fluoroquinolones involves interaction with enzymes essential for major DNA functions such as replication, transcription, and recombination. The primary targets for Pradofloxacin are the bacterial DNA gyrase and topoisomerase IV enzymes. Reversible association between Pradofloxacin and DNA gyrase or DNA topoisomerase IV in the target bacteria results in inhibition of these enzymes and rapid death of the bacterial cell. The rapidity and extent of bacterial killing are directly proportional to the drug concentration.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Antimicrobial drug susceptibility of Staphylococcus intermedius clinical isolates from canine pyoderma. | 2005 Feb |
|
| In vivo tolerance and kinetics of a novel ocular drug delivery device. | 2006 Nov 28 |
|
| Pradofloxacin in the treatment of canine deep pyoderma: a multicentred, blinded, randomized parallel trial. | 2007 Jun |
|
| Mutant prevention concentration of pradofloxacin against Porphyromonas gingivalis. | 2007 Mar 31 |
|
| Identification of Qnr and AAC(6')-1b-cr plasmid-mediated fluoroquinolone resistance determinants in multidrug-resistant Enterobacter spp. isolated from extraintestinal infections in companion animals. | 2010 Jul 14 |
|
| Haemotropic mycoplasmas: what's their real significance in cats? | 2010 May |
|
| Fluoroquinolone resistance mechanisms in multidrug-resistant Escherichia coli isolated from extraintestinal infections in dogs. | 2010 Nov 20 |
|
| Evaluation of the clinical efficacy of pradofloxacin tablets for the treatment of canine pyoderma. | 2010 Sep-Oct |
Patents
Sample Use Guides
Administer 3.0 mg/kg bodyweight of pradofloxacin once daily.
Route of Administration:
Oral
The MIC of pradofloxacinc was determined by broth microdilution according to Clinical and Laboratory Standards Institute (CLSI) standards,6 within the concentration range 0.008–16 μg/mL. The MICs of enrofloxacin and ciprofloxacin were determined using commercial stripsd on Mueller–Hinton 2 agar inoculated with a bacterial suspension (density of 0.5 McFarland) and incubated for 24 h at 35°C. The reference strain S. aureus ATCC 25923 was used as a quality control for MIC determination with the commercial strips, according to the manufacturer’s instructions.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 19:50:45 GMT 2023
by
admin
on
Sat Dec 16 19:50:45 GMT 2023
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| Record UNII |
T9J58ERF3L
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| Record Status |
Validated (UNII)
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| Record Version |
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67315146
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T9J58ERF3L
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866760-50-1
Created by
admin on Sat Dec 16 19:50:45 GMT 2023 , Edited by admin on Sat Dec 16 19:50:45 GMT 2023
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