PSI-7409

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C10H16FN2O14P3
Molecular Weight	500.1587
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@@]1(F)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1N2C=CC(=O)NC2=O

InChI

InChIKey=IPHULAIUXUVCHH-VPCXQMTMSA-N

InChI=1S/C10H16FN2O14P3/c1-10(11)7(15)5(25-8(10)13-3-2-6(14)12-9(13)16)4-24-29(20,21)27-30(22,23)26-28(17,18)19/h2-3,5,7-8,15H,4H2,1H3,(H,20,21)(H,22,23)(H,12,14,16)(H2,17,18,19)/t5-,7-,8-,10-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C10H16FN2O14P3
Molecular Weight	500.1587
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

PubMed

Title	Date	PubMed
Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor beta-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine (PSI-6130) and identification of a novel active 5'-triphosphate species.	2007 Oct 12	17698842
PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication.	2010 Aug	20516278

Substance Class	Chemical Created by `admin` on `Sat Dec 16 10:46:27 GMT 2023` Edited by `admin` on `Sat Dec 16 10:46:27 GMT 2023`
Record UNII	T90A75S60M
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PSI-7409

Common Name

English

DIHYDROXYPHOSPHORYL (((2R,3R,4R,5R)-5-(2,4-DIOXOPYRIMIDIN-1-YL)-4-FLUORO-3-HYDROXY-4-METHYL-TETRAHYDROFURAN-2-YL)METHOXY-HYDROXY-PHOSPHORYL) HYDROGEN PHOSPHATE

Systematic Name

English

URIDINE 5'-(TETRAHYDROGEN TRIPHOSPHATE), 2'-DEOXY-2'-FLUORO-2'-METHYL-, (2'R)-

Common Name

English

GS-461203

Common Name

English

Code System Code Type Description

CAS

1015073-42-3

Created by admin on Sat Dec 16 10:46:28 GMT 2023 , Edited by admin on Sat Dec 16 10:46:28 GMT 2023

PRIMARY

FDA UNII

T90A75S60M

Created by admin on Sat Dec 16 10:46:28 GMT 2023 , Edited by admin on Sat Dec 16 10:46:28 GMT 2023

PRIMARY

PUBCHEM

23725128

Created by admin on Sat Dec 16 10:46:28 GMT 2023 , Edited by admin on Sat Dec 16 10:46:28 GMT 2023

PRIMARY

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SOFOSBUVIR

PRODRUG -> METABOLITE ACTIVE

Interaction Type:

MINOR

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					T90A75S60M

PSI-7409

ACTIVE MOIETY