Zeleciment basivarsen

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 18:54:43 GMT 2025` Edited by `admin` on `Wed Apr 02 18:54:43 GMT 2025`
Protein Type	FAB
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	T7PH26YY2C
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Fab-G1 VH-CH1 chain (1-227) [VH Musmus/Homsap (Mus musculus IGHV3-6*01 (84.5%) -(IGHD) -IGHJ2*01 (85.7%)L124>V (115)/Homo sapiens IGHV4-30-4*01 (82.8%) -(IGHD) -IGHJ4*01 (85.7%) L123>T (114), CDR-IMGT [9.7.12] (26-34.52-58.97-108)) (1-119) -Homo sapiens

Preferred Name

English

Zeleciment basivarsen

Official Name

English

immunoglobulin Fab G1-kappa (VH-CH1_L-kappa), anti-[Homo sapiens TFRC (transferrin receptor, TfR1, TFR1, CD71)], monoclonal antibody; substituted at N6 of lysine residues with basivarsen groups

Common Name

English

Immunoglobulin G1 Fab fragment, anti-(human and Macaca fascicularis transferrin receptors type 1) (human-Mus musculus monoclonal F5298 ?1-chain), disulfide with human-Mus musculus monoclonal F5298 ?-chain, N6-amide with DNA d(P-thio)((2?-O,4?-C-methylene

Common Name

English

zeleciment basivarsen [INN]

Common Name

English

Code System Code Type Description

CAS

2767191-74-0

Created by admin on Wed Apr 02 18:54:43 GMT 2025 , Edited by admin on Wed Apr 02 18:54:43 GMT 2025

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FDA UNII

T7PH26YY2C

Created by admin on Wed Apr 02 18:54:43 GMT 2025 , Edited by admin on Wed Apr 02 18:54:43 GMT 2025

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INN

12713

Created by admin on Wed Apr 02 18:54:43 GMT 2025 , Edited by admin on Wed Apr 02 18:54:43 GMT 2025

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NCI_THESAURUS

C203157

Created by admin on Wed Apr 02 18:54:43 GMT 2025 , Edited by admin on Wed Apr 02 18:54:43 GMT 2025

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From	To
1_222	2_214
2_134	2_194
2_23	2_88
1_146	1_202
1_22	1_96

Related Record Type Details


					X9E1Y3I7P0

MYOTONIN-PROTEIN KINASE

TARGET->INHIBITOR OF EXPRESSION

Amount:


					F3QH9IU2HT

TRANSFERRIN RECEPTOR PROTEIN 1

TARGET->LIGAND

Amount:


					F6J6Y9R4HT

Zeleciment

PARENT -> CONJUGATE

Amount:

Related Record Type Details


					T7PH26YY2C

Zeleciment basivarsen

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION		RESIDUE_SPECIFIC			Cytidine-basivarsen-lysine	2LVD3H594X
AMINO_ACID_SUBSTITUTION	[1_1]	N-TERMINUS		Amount:	PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL