Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C25H34N6O4S |
| Molecular Weight | 514.64 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCNC1=NC2=C(C=N1)C(=NN2[C@H]3CC[C@H](O)CC3)C4=CC=C(C=C4)S(=O)(=O)N5CCOCC5
InChI
InChIKey=KAAPXWSYROPAEL-MXVIHJGJSA-N
InChI=1S/C25H34N6O4S/c1-2-3-12-26-25-27-17-22-23(29-31(24(22)28-25)19-6-8-20(32)9-7-19)18-4-10-21(11-5-18)36(33,34)30-13-15-35-16-14-30/h4-5,10-11,17,19-20,32H,2-3,6-9,12-16H2,1H3,(H,26,27,28)/t19-,20-
| Molecular Formula | C25H34N6O4S |
| Molecular Weight | 514.64 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
DescriptionCurator's Comment: Description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/23585477 | https://www.ncbi.nlm.nih.gov/pubmed/27081701 | https://www.ncbi.nlm.nih.gov/pubmed/25965821
Curator's Comment: Description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/23585477 | https://www.ncbi.nlm.nih.gov/pubmed/27081701 | https://www.ncbi.nlm.nih.gov/pubmed/25965821
UNC1062, pyrazolopyrimidine sulfonamide, was identified as a potent and selective inhibitor of C-MER proto-oncogene tyrosine kinase (MERTK. C-MER proto-oncogene tyrosine kinase (MERTK) is a receptor tyrosine kinase with oncogenic properties that is often overexpressed or activated in various malignancies. UNC1062 induced apoptosis in culture, reduced colony formation in soft agar, and inhibited invasion of melanoma cells. UNC1062 attenuates neoplastic phenotype in solid tumor cell lines: reduces cell motility in head and neck cancer cells, inhibits proliferation in gastric cancer cells and inhibits colony formation in non-small cell lung cancer cells.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| UNC1062, a new and potent Mer inhibitor. | 2013 Jul |
|
| MERTK receptor tyrosine kinase is a therapeutic target in melanoma. | 2013 May |
|
| UNC2025, a potent and orally bioavailable MER/FLT3 dual inhibitor. | 2014 Aug 28 |
|
| MERTK as a novel therapeutic target in head and neck cancer. | 2016 May 31 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:07:40 GMT 2023
by
admin
on
Fri Dec 15 16:07:40 GMT 2023
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| Record UNII |
T7755XP5Y6
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| Record Status |
Validated (UNII)
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| Record Version |
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-
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1350549-36-8
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T7755XP5Y6
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68212798
Created by
admin on Fri Dec 15 16:07:40 GMT 2023 , Edited by admin on Fri Dec 15 16:07:40 GMT 2023
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