UNC1062, pyrazolopyrimidine sulfonamide, was identified as a potent and selective inhibitor of C-MER proto-oncogene tyrosine kinase (MERTK. C-MER proto-oncogene tyrosine kinase (MERTK) is a receptor tyrosine kinase with oncogenic properties that is often overexpressed or activated in various malignancies. UNC1062 induced apoptosis in culture, reduced colony formation in soft agar, and inhibited invasion of melanoma cells. UNC1062 attenuates neoplastic phenotype in solid tumor cell lines: reduces cell motility in head and neck cancer cells, inhibits proliferation in gastric cancer cells and inhibits colony formation in non-small cell lung cancer cells.