5,7-DICHLOROKYNURENIC ACID

OC(=O)C1=NC2=C(C(O)=C1)C(Cl)=CC(Cl)=C2

InChIKey=BGKFPRIGXAVYNX-UHFFFAOYSA-N

InChI=1S/C10H5Cl2NO3/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14/h1-3H,(H,13,14)(H,15,16)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Condition	Potency
Glutamate [NMDA] receptor 125 Target ID: CHEMBL2094124 Sources: https://www.sciencedirect.com/science/article/pii/S0960894X00800955?via%3Dihub	Antagonist 2778		68.0 nM [IC50]

PubMed

Title	Date	PubMed
Yohimbine-induced seizures involve NMDA and GABAergic transmission.	1992 Apr	1326092
Excitatory amino acid neurotransmission through both NMDA and non-NMDA receptors is involved in the anticonvulsant activity of felbamate in DBA/2 mice.	1994 Sep 1	7529182
Anticonvulsant activity of 5,7DCKA, NBQX, and felbamate against some chemoconvulsants in DBA/2 mice.	1996 Oct	8951966
The role of striatal glutamate receptors in models of Parkinson's disease.	1998	9871435
Contribution of the glycine site of NMDA receptors in rostral and intermediate-caudal parts of the striatum to the regulation of muscle tone in rats.	1998 May 18	9630698
Selective antagonism of rat inhibitory glycine receptor subunits.	2004 Feb 1	14645455
Model structures of the N-methyl-D-aspartate receptor subunit NR1 explain the molecular recognition of agonist and antagonist ligands.	2004 Mar	14960371

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:39:14 GMT 2023` Edited by `admin` on `Fri Dec 15 19:39:14 GMT 2023`
Record UNII	T61ORK73PY
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

5,7-DICHLOROKYNURENIC ACID

Common Name

English

5,7-Dichloro-4-hydroxy-2-quinolinecarboxylic acid

Systematic Name

English

2-Quinolinecarboxylic acid, 5,7-dichloro-4-hydroxy-

Systematic Name

English

5,7-DCKA

Common Name

English

Kynurenic acid, 5,7-dichloro-

Common Name

English

Code System Code Type Description

WIKIPEDIA

5,7-Dichlorokynurenic acid