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Details

Stereochemistry ACHIRAL
Molecular Formula C18H31N3O3S.C4H4O4
Molecular Weight 485.594
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of SURICAINIDE MALEATE

SMILES

OC(=O)\C=C/C(O)=O.CCN(CC)CCNC(=O)N(CCS(=O)(=O)C1=CC=CC=C1)C(C)C

InChI

InChIKey=CMKAKNPPMGLPRW-BTJKTKAUSA-N
InChI=1S/C18H31N3O3S.C4H4O4/c1-5-20(6-2)13-12-19-18(22)21(16(3)4)14-15-25(23,24)17-10-8-7-9-11-17;5-3(6)1-2-4(7)8/h7-11,16H,5-6,12-15H2,1-4H3,(H,19,22);1-2H,(H,5,6)(H,7,8)/b;2-1-

HIDE SMILES / InChI

Molecular Formula C18H31N3O3S
Molecular Weight 369.522
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C4H4O4
Molecular Weight 116.0722
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Suricainide (also known as AHR 10718) is an aminoalkylurea derivative patented by A. H. Robins Co., Inc. as an antiarrhythmic agent. Suricainide induces a use-dependent decrease in Vmax and significantly decreased Purkinje fiber conduction velocity and action potential duration. Suricainide had no effect on slow response action potentials induced by isoproterenol but ventricular muscle action potentials were significantly prolonged by Suricainide. Suricainide significantly decreased normal automaticity, catecholamine-enhanced automaticity, and abnormal automaticity induced by barium or myocardial infarction. In preclinical modes, Suricainide suppresses the aconitine-induced canine atrial arrhythmia.

Approval Year

PubMed

PubMed

TitleDatePubMed
Electrophysiologic effects of AHR 10718 on isolated cardiac tissues.
1985 Feb 5
Patents

Patents

Sample Use Guides

Dog 10 mg/kg
Route of Administration: Intravenous
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:04:11 UTC 2023
Edited
by admin
on Fri Dec 15 15:04:11 UTC 2023
Record UNII
T51D479OZJ
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SURICAINIDE MALEATE
USAN  
USAN  
Official Name English
SURICAINIDE MALEATE [USAN]
Common Name English
AHR-10718
Code English
Classification Tree Code System Code
NCI_THESAURUS C47793
Created by admin on Fri Dec 15 15:04:11 UTC 2023 , Edited by admin on Fri Dec 15 15:04:11 UTC 2023
Code System Code Type Description
ChEMBL
CHEMBL2110719
Created by admin on Fri Dec 15 15:04:11 UTC 2023 , Edited by admin on Fri Dec 15 15:04:11 UTC 2023
PRIMARY
CAS
85053-47-0
Created by admin on Fri Dec 15 15:04:11 UTC 2023 , Edited by admin on Fri Dec 15 15:04:11 UTC 2023
PRIMARY
NCI_THESAURUS
C152478
Created by admin on Fri Dec 15 15:04:11 UTC 2023 , Edited by admin on Fri Dec 15 15:04:11 UTC 2023
PRIMARY
FDA UNII
T51D479OZJ
Created by admin on Fri Dec 15 15:04:11 UTC 2023 , Edited by admin on Fri Dec 15 15:04:11 UTC 2023
PRIMARY
USAN
X-69
Created by admin on Fri Dec 15 15:04:11 UTC 2023 , Edited by admin on Fri Dec 15 15:04:11 UTC 2023
PRIMARY
PUBCHEM
6439931
Created by admin on Fri Dec 15 15:04:11 UTC 2023 , Edited by admin on Fri Dec 15 15:04:11 UTC 2023
PRIMARY
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ACTIVE MOIETY