ZIPALERTINIB

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C23H20N6O
Molecular Weight	396.4445
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=C[C@@H](CN2C3=NC=NC(N)=C3C(=C12)C4=CC5=C(C=CC=C5)N=C4)NC(=O)C=C

InChI

InChIKey=MKCYPWYURWOKST-INIZCTEOSA-N

InChI=1S/C23H20N6O/c1-3-18(30)28-16-8-13(2)21-19(15-9-14-6-4-5-7-17(14)25-10-15)20-22(24)26-12-27-23(20)29(21)11-16/h3-10,12,16H,1,11H2,2H3,(H,28,30)(H2,24,26,27)/t16-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C23H20N6O
Molecular Weight	396.4445
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

C_max

Value	Dose	Co-administered	Analyte	Population
316 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/37384848/	100 mg 2 times / day multiple, oral dose: 100 mg route of administration: Oral experiment type: MULTIPLE co-administered:		ZIPALERTINIB plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

AUC

Value	Dose	Co-administered	Analyte	Population
1029 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/37384848/	100 mg 2 times / day multiple, oral dose: 100 mg route of administration: Oral experiment type: MULTIPLE co-administered:		ZIPALERTINIB plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

T_1/2

Value	Dose	Co-administered	Analyte	Population
4 h REVIEW https://cullinantherapeutics.com/wp-content/uploads/2023/01/cullinan-pearl-safety-1345P.pdf	100 mg 2 times / day multiple, oral dose: 100 mg route of administration: Oral experiment type: MULTIPLE co-administered:		ZIPALERTINIB plasma	Homo sapiens population: UNKNOWN age: UNKNOWN sex: UNKNOWN food status: UNKNOWN
3.6 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/37384848/	100 mg 2 times / day multiple, oral dose: 100 mg route of administration: Oral experiment type: MULTIPLE co-administered:		ZIPALERTINIB plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

Substance Class	Chemical Created by `admin` on `Wed Apr 02 00:48:41 GMT 2025` Edited by `admin` on `Wed Apr 02 00:48:41 GMT 2025`
Record UNII	T4YMU8TW9H
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

CLN-081

Preferred Name

English

ZIPALERTINIB

Official Name

English

TAS-6417

Code

English

ZIPALERTINIB [USAN]

Common Name

English

CLN081

Code

English

TPC064

Code

English

TPC-064

Code

English

zipalertinib [INN]

Common Name

English

TAS6417

Code

English

2-PROPENAMIDE, N-((8S)-4-AMINO-8,9-DIHYDRO-6-METHYL-5-(3-QUINOLINYL)PYRIMIDO(5,4-B)INDOLIZIN-8-YL)-

Systematic Name

English

Zipalertinib [WHO-DD]

Common Name

English

Code System Code Type Description

INN

11972