Onvuzosiran sodium

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Wed Apr 02 20:10:52 GMT 2025` Edited by `admin` on `Wed Apr 02 20:10:52 GMT 2025`
Nucleic Acid Type	siRNA
Sequence Origin	SYNTHETIC
Sequence Type	COMPLETE
Record UNII	T4XC2DH9BM
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Onvuzosiran sodium

Common Name

English

RNA, ([3?-O-[2-[[[1-[17-[[2-(acetylamino)-2-deoxy-?-D-galactopyranosyl]oxy]-3,6,9,12,15-pentaoxaheptadec-1-yl]-1H-1,2,3-triazol-4-yl]methyl]amino]-2-oxoethyl]-2?-O-[2-[bis[[1-[17-[[2-(acetylamino)-2-deoxy-?-D-galactopyranosyl]oxy]-3,6,9,12,15-pentaoxahep

Preferred Name

English

Code System Code Type Description

FDA UNII

T4XC2DH9BM

Created by admin on Wed Apr 02 20:10:52 GMT 2025 , Edited by admin on Wed Apr 02 20:10:52 GMT 2025

PRIMARY

CAS

2982817-51-4

Created by admin on Wed Apr 02 20:10:52 GMT 2025 , Edited by admin on Wed Apr 02 20:10:52 GMT 2025

PRIMARY

Sugar	Site Range	Site Count
	1_23	1 / 46
2'-Fluoro-Ribose	1_8;1_10-1_13;2_2;2_4;2_6;2_8;2_10;2_12;2_14;2_16;2_18;2_20	15 / 46
	1_1	1 / 46
2'-O-Methyl-Ribose	1_2-1_7;1_9;1_14-1_22;2_1;2_3;2_5;2_7;2_9;2_11;2_13;2_15;2_17;2_19;2_21-2_23	29 / 46

Linkage	Site Range	Site Count
	1_4-1_21;2_4-2_21	36 / 44
Sodium Phosporothioate	1_2-1_3;1_22-1_23;2_2-2_3;2_22-2_23	8 / 44

Related Record Type Details


					MC7ZD4X9KB

Onvuzosiran

PARENT -> SALT/SOLVATE

Amount:

Related Record Type Details


					MC7ZD4X9KB

Onvuzosiran

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOTIDE SUBSTITUTION	[1_1]	5'-TERMINUS	C		UNSPECIFIED SUBSTANCE	14ece05d (not in database)
NUCLEOTIDE SUBSTITUTION	[1_23]	3'-TERMINUS	Abasic		1,2-Dideoxy-D-ribofuranose 3-phosphorothioate sodium	ZF4XY3EE8G