Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C34H38N4O6.ClH |
Molecular Weight | 635.15 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CC[C@@]1(O)C(=O)OCC2=C1C=C3N(CC4=C3N=C5C=CC(OC(=O)N6CCC(CC6)N7CCCCC7)=C(CC=C)C5=C4)C2=O
InChI
InChIKey=UWNITDCAZZJJFF-GXUZKUJRSA-N
InChI=1S/C34H38N4O6.ClH/c1-3-8-23-24-17-21-19-38-28(18-26-25(31(38)39)20-43-32(40)34(26,42)4-2)30(21)35-27(24)9-10-29(23)44-33(41)37-15-11-22(12-16-37)36-13-6-5-7-14-36;/h3,9-10,17-18,22,42H,1,4-8,11-16,19-20H2,2H3;1H/t34-;/m0./s1
Molecular Formula | C34H38N4O6 |
Molecular Weight | 598.6887 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Molecular Formula | ClH |
Molecular Weight | 36.461 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
HaiHe Biopharma (Shanghai HaiHe Pharmaceutical) is developing simmitecan, an ester pro-drug of chimmitecan for the treatment of cancer. Simmitecan is in phase I development for solid tumours and colorectal cancer in China. Simmitecan (L-P) is a water-soluble ester prodrug of chimmitecan (L-2-Z) with potent anti-tumor activities in different experimental animals. Chimmitecan,a novel CPT derivative, exhibited potent antitumor activities both in vitro and in vivo by inhibiting topoisomerase I.
Originator
Approval Year
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/24056706
SD rats were injected with a single iv bolus doses of Simmitecan (3.75, 7.5 and 15 mg/kg).
Route of Administration:
Intravenous
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:41:09 GMT 2023
by
admin
on
Sat Dec 16 08:41:09 GMT 2023
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Record UNII |
T4H02O147G
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Record Status |
Validated (UNII)
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Record Version |
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Systematic Name | English |
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NCI_THESAURUS |
C2843
Created by
admin on Sat Dec 16 08:41:09 GMT 2023 , Edited by admin on Sat Dec 16 08:41:09 GMT 2023
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71587955
Created by
admin on Sat Dec 16 08:41:09 GMT 2023 , Edited by admin on Sat Dec 16 08:41:09 GMT 2023
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PRIMARY | |||
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T4H02O147G
Created by
admin on Sat Dec 16 08:41:09 GMT 2023 , Edited by admin on Sat Dec 16 08:41:09 GMT 2023
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PRIMARY | |||
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C106369
Created by
admin on Sat Dec 16 08:41:09 GMT 2023 , Edited by admin on Sat Dec 16 08:41:09 GMT 2023
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PRIMARY | NCIT | ||
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1247847-78-4
Created by
admin on Sat Dec 16 08:41:09 GMT 2023 , Edited by admin on Sat Dec 16 08:41:09 GMT 2023
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PRIMARY |
Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE |
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ACTIVE MOIETY |