TISOTUMAB VEDOTIN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 16:24:54 GMT 2025` Edited by `admin` on `Tue Apr 01 16:24:54 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type	IGG1
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	T41737F88A
Record Status	`Validated (UNII)`
Record Version

Download

Related Record	Type

Name

Type

Language

TISOTUMAB VEDOTIN

Official Name

English

GCT1015-04

Preferred Name

English

IMMUNOGLOBULIN G1, ANTI-(HUMAN BLOOD-COAGULATION FACTOR III) (HUMAN MONOCLONAL HUMAX-TF HEAVY CHAIN), DISULFIDE WITH HUMAN MONOCLONAL HUMAX-TF .KAPPA.-CHAIN, DIMER, TETRAKIS(THIOETHER) WITH N-(((4-((N-(6-(3-MERCAPTO-2,5-DIOXO-1-PYRROLIDINYL)-1-OXOHEXYL)-

Common Name

English

TISOTUMAB VEDOTIN [JAN]

Common Name

English

TISOTUMAB VEDOTIN [USAN]

Common Name

English

Tisotumab vedotin [WHO-DD]

Common Name

English

IMMUNOGLOBULIN G1-KAPPA, ANTI-(HOMO SAPIENS TISSUE FACTOR (COAGULATION FACTOR III, THROMBOPLASTIN, CD142 ANTIGEN, TF))HOMO SAPIENS MONOCLONAL ANTIBODY.GAMMA.1 HEAVY CHAIN (1-448) (HOMO SAPIENS VH (IGHV3-23*01 (94%) (IGHD)-IGHJ5*01 (87%)) (8.8.11) (1-118)

Common Name

English

HUMAX-TF-ADC

Code

English

HUMAXTFADC

Common Name

English

IGG1-1015-011-1006

Code

English

tisotumab vedotin [INN]

Common Name

English

TF-011-MMAE

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C129823

Created by admin on Tue Apr 01 16:24:54 GMT 2025 , Edited by admin on Tue Apr 01 16:24:54 GMT 2025

NCI_THESAURUS

C20401

Created by admin on Tue Apr 01 16:24:54 GMT 2025 , Edited by admin on Tue Apr 01 16:24:54 GMT 2025

NCI_THESAURUS

C1742

Created by admin on Tue Apr 01 16:24:54 GMT 2025 , Edited by admin on Tue Apr 01 16:24:54 GMT 2025

Code System Code Type Description

RXCUI

2571094

Created by admin on Tue Apr 01 16:24:54 GMT 2025 , Edited by admin on Tue Apr 01 16:24:54 GMT 2025

PRIMARY

DAILYMED

T41737F88A

Created by admin on Tue Apr 01 16:24:54 GMT 2025 , Edited by admin on Tue Apr 01 16:24:54 GMT 2025

PRIMARY

FDA UNII

T41737F88A

Created by admin on Tue Apr 01 16:24:54 GMT 2025 , Edited by admin on Tue Apr 01 16:24:54 GMT 2025

PRIMARY

SMS_ID

100000177096

Created by admin on Tue Apr 01 16:24:54 GMT 2025 , Edited by admin on Tue Apr 01 16:24:54 GMT 2025

PRIMARY

USAN

GH-177

Created by admin on Tue Apr 01 16:24:54 GMT 2025 , Edited by admin on Tue Apr 01 16:24:54 GMT 2025

PRIMARY

WIKIPEDIA

Tisotumab vedotin

Created by admin on Tue Apr 01 16:24:54 GMT 2025 , Edited by admin on Tue Apr 01 16:24:54 GMT 2025

PRIMARY

CAS

1418731-10-8

Created by admin on Tue Apr 01 16:24:54 GMT 2025 , Edited by admin on Tue Apr 01 16:24:54 GMT 2025

PRIMARY

INN

10148

Created by admin on Tue Apr 01 16:24:54 GMT 2025 , Edited by admin on Tue Apr 01 16:24:54 GMT 2025

PRIMARY

NCI_THESAURUS

C113164

Created by admin on Tue Apr 01 16:24:54 GMT 2025 , Edited by admin on Tue Apr 01 16:24:54 GMT 2025

PRIMARY

From	To
1_22	1_96
1_145	1_201
1_262	1_322
1_368	1_426
2_22	2_96
2_145	2_201
2_262	2_322
2_368	2_426
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194
1_221	3_214
2_221	4_214
1_227	2_227
1_230	2_230

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_298
N	2_298

Related Record Type Details


					1U5PI2DLU1

TARGET->CONJUGATED TOXIN

Amount:


					Q3606FDE0B

VEDOTIN FRAGMENT

CONJUGATE COMPONENT->CONJUGATE

Amount:


					Q3606FDE0B

VEDOTIN FRAGMENT

CONJUGATE COMPONENT->CONJUGATE

Qualification:

DEPENDENCY

Amount:


					6603L01WUR

Cysteinyl vedotin

CONJUGATE COMPONENT->CONJUGATE

Amount:

TISOTUMAB VEDOTIN-TFTV

SUB_CONCEPT->SUBSTANCE

Amount:


					IXO40TAF8X

TISOTUMAB

PARENT -> DERIVATIVE

Amount:

Related Record Type Details


					T41737F88A

TISOTUMAB VEDOTIN

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION		RESIDUE_SPECIFIC	C	Amount:	Cysteinyl vedotin	6603L01WUR

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL