THIOIMIDODICARBONIC DIAMIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C2H5N3S2
Molecular Weight	135.211
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of THIOIMIDODICARBONIC DIAMIDE

Structure Search

SMILES

NC(=S)NC(N)=S

InChI

InChIKey=JIRRNZWTWJGJCT-UHFFFAOYSA-N

InChI=1S/C2H5N3S2/c3-1(6)5-2(4)7/h(H5,3,4,5,6,7)

HIDE SMILES / InChI

Molecular Formula	C2H5N3S2
Molecular Weight	135.211
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/12466444 | https://www.ncbi.nlm.nih.gov/pubmed/7531763

Thioimidodicarbonic diamide (Dithiobiuret) is an organosulfur compound used as a plasticizer, a rubber accelerator and as an intermediate in pesticide manufacturing. Chronic administration of dithiobiuret induces a neuromuscular syndrome of flaccid muscle weakness. Mechanisms underlying this effect involve disruptions of acetylcholine (ACh) release and possibly modulation of the ACh receptor channel complex functioning.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Muscle-type nicotinic acetylcholine receptor 65 Target ID: CHEMBL2362997 Sources: Dithiobiuret decreased mean open time of ion channels.	Modulator 828

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed
Impairment of synaptic vesicle exocytosis and recycling during neuromuscular weakness produced in mice by 2,4-dithiobiuret.	2002 Dec	12466444
Morphometric characterization of the neuromuscular junction of rodents intoxicated with 2,4-dithiobiuret: evidence that nerve terminal recycling processes contribute to muscle weakness.	2004 Apr 15	15081273
Toxicological evaluation of the staircase test for assessing fine motor movements.	2004 Jan-Feb	15001220
Synaptic cysteine sulfhydryl groups as targets of electrophilic neurotoxicants.	2006 Dec	16880199
SNARE-dependent glutamate release in megakaryocytes.	2010 Jun	20347926
Loss of STOP protein impairs peripheral olfactory neurogenesis.	2010 Sep 15	20856814

Patents

Sample Use Guides

In Vivo Use Guide

To induce muscle weakness, dithiobiuret was injected intraperitoneally for 6 days at 1mg/kg.

Route of Administration: Intraperitoneal

In Vitro Use Guide

Effect of dithiobiuret (DTB) on AChR channel currents was recorded from G8 myotubes. Currents were recorded using standard patch voltage-clamp techniques on cell-free patches in the “outside-out” configuration. DTB was applied at concentrations 1-10 uM.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:08:17 GMT 2023` Edited by `admin` on `Fri Dec 15 19:08:17 GMT 2023`
Record UNII	T40X2KXL53
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

THIOIMIDODICARBONIC DIAMIDE

Systematic Name

English

2,4-DITHIOBIURET [MI]

Common Name

English

DITHIOBIURET

Systematic Name

English

2,4-DITHIOBIURET

Systematic Name

English

THIOIMIDODICARBONICDIAMIDE

Systematic Name

English

NSC-7761

Code

English

2,4-DITHIOBIURET [HSDB]

Common Name

English

Code System Code Type Description

FDA UNII

T40X2KXL53