THIOIMIDODICARBONIC DIAMIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C2H5N3S2
Molecular Weight	135.211
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of THIOIMIDODICARBONIC DIAMIDE

Structure Search

SMILES

NC(=S)NC(N)=S

InChI

InChIKey=JIRRNZWTWJGJCT-UHFFFAOYSA-N

InChI=1S/C2H5N3S2/c3-1(6)5-2(4)7/h(H5,3,4,5,6,7)

HIDE SMILES / InChI

Molecular Formula	C2H5N3S2
Molecular Weight	135.211
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/12466444 | https://www.ncbi.nlm.nih.gov/pubmed/7531763

Thioimidodicarbonic diamide (Dithiobiuret) is an organosulfur compound used as a plasticizer, a rubber accelerator and as an intermediate in pesticide manufacturing. Chronic administration of dithiobiuret induces a neuromuscular syndrome of flaccid muscle weakness. Mechanisms underlying this effect involve disruptions of acetylcholine (ACh) release and possibly modulation of the ACh receptor channel complex functioning.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Muscle-type nicotinic acetylcholine receptor 65 Target ID: CHEMBL2362997 Sources: Dithiobiuret decreased mean open time of ion channels.	Modulator 846

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2596

PubMed

Title	Date	PubMed
Loss of STOP protein impairs peripheral olfactory neurogenesis.	2010-09-15	20856814
SNARE-dependent glutamate release in megakaryocytes.	2010-06	20347926
Synaptic cysteine sulfhydryl groups as targets of electrophilic neurotoxicants.	2006-12	16880199
Morphometric characterization of the neuromuscular junction of rodents intoxicated with 2,4-dithiobiuret: evidence that nerve terminal recycling processes contribute to muscle weakness.	2004-04-15	15081273
Toxicological evaluation of the staircase test for assessing fine motor movements.	2003-07-10	15001220
Impairment of synaptic vesicle exocytosis and recycling during neuromuscular weakness produced in mice by 2,4-dithiobiuret.	2002-12	12466444

Patents

Sample Use Guides

In Vivo Use Guide

To induce muscle weakness, dithiobiuret was injected intraperitoneally for 6 days at 1mg/kg.

Route of Administration: Intraperitoneal

In Vitro Use Guide

Effect of dithiobiuret (DTB) on AChR channel currents was recorded from G8 myotubes. Currents were recorded using standard patch voltage-clamp techniques on cell-free patches in the “outside-out” configuration. DTB was applied at concentrations 1-10 uM.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:33:03 GMT 2025` Edited by `admin` on `Mon Mar 31 19:33:03 GMT 2025`
Record UNII	T40X2KXL53
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

2,4-DITHIOBIURET

Preferred Name

English

THIOIMIDODICARBONIC DIAMIDE

Systematic Name

English

2,4-DITHIOBIURET [MI]

Common Name

English

DITHIOBIURET

Systematic Name

English

THIOIMIDODICARBONICDIAMIDE

Systematic Name

English

NSC-7761

Code

English

2,4-DITHIOBIURET [HSDB]

Common Name

English

Code System Code Type Description

FDA UNII

T40X2KXL53