FLUOROESTRADIOL F-18

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C18H23FO2
Molecular Weight	289.375
Optical Activity	UNSPECIFIED
Defined Stereocenters	6 / 6
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12C[C@@H]([18F])[C@H](O)[C@@]1(C)CC[C@]3([H])C4=C(CC[C@@]23[H])C=C(O)C=C4

InChI

InChIKey=KDLLNMRYZGUVMA-ZYMZXAKXSA-N

InChI=1S/C18H23FO2/c1-18-7-6-13-12-5-3-11(20)8-10(12)2-4-14(13)15(18)9-16(19)17(18)21/h3,5,8,13-17,20-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17+,18+/m1/s1/i19-1

HIDE SMILES / InChI

Molecular Formula	C18H23FO2
Molecular Weight	289.375
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	6 / 6
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/27307345 | https://www.ncbi.nlm.nih.gov/pubmed/28798032

Fluoroestradiol F-18 is a derivative of estradiol. where hydrogen at position 16 is replaced by radioactive fluorine. Fluoroestradiol F-18 is taken up by tumor cells, expression estrogen receptor, and it is clinically evaluated for PET imaging to detect and stage breast cancer, ovarian cancer, and cancer of uterine endometrium and myometrium.

Approval Year

PubMed

Title	Date	PubMed
18F-Fluoroestradiol PET: Current Status and Potential Future Clinical Applications.	2016 Aug	27307345
Improved Estrogen Receptor Assessment by PET Using the Novel Radiotracer (18)F-4FMFES in Estrogen Receptor-Positive Breast Cancer Patients: An Ongoing Phase II Clinical Trial.	2018 Feb	28798032

Substance Class	Chemical Created by `admin` on `Thu Jul 06 12:52:47 UTC 2023` Edited by `admin` on `Thu Jul 06 12:52:47 UTC 2023`
Record UNII	T32277KB09
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FLUOROESTRADIOL F-18

Common Name

English

CERIANNA

Brand Name

English

ESTRA-1,3,5(10)-TRIENE-3,17-DIOL, 16-(FLUORO-18F)-, (16.ALPHA.,17.BETA.)-

Systematic Name

English

FES F-18

Common Name

English

16.ALPHA.-(18F)FLUOROESTRADIOL

Common Name

English

F-18 16-ALPHA-FLUOROESTRADIOL

Common Name

English

FLUOROESTRADIOL F18

Common Name

English

(18F)-FES

Common Name

English

16.ALPHA.-(18F)FLUORO-17.BETA.-ESTRADIOL

Common Name

English

Fluoroestradiol (18F) [WHO-DD]

Common Name

English

FLUOROESTRADIOL F-18 [ORANGE BOOK]

Common Name

English

NSC-743445

Code

English

F-18 FES

Common Name

English

F-18 16 ALPHA-FLUOROESTRADIOL

Common Name

English

FLUOROESTRADIOL F18 [MI]

Common Name

English

Classification Tree Code System Code

WHO-ATC

V09IX11