Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C18H23FO2 |
| Molecular Weight | 289.375 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 6 / 6 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12C[C@@H]([18F])[C@H](O)[C@@]1(C)CC[C@]3([H])C4=C(CC[C@@]23[H])C=C(O)C=C4
InChI
InChIKey=KDLLNMRYZGUVMA-ZYMZXAKXSA-N
InChI=1S/C18H23FO2/c1-18-7-6-13-12-5-3-11(20)8-10(12)2-4-14(13)15(18)9-16(19)17(18)21/h3,5,8,13-17,20-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17+,18+/m1/s1/i19-1
| Molecular Formula | C18H23FO2 |
| Molecular Weight | 289.375 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 6 / 6 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Fluoroestradiol F-18 is a derivative of estradiol. where hydrogen at position 16 is replaced by radioactive fluorine. Fluoroestradiol F-18 is taken up by tumor cells, expression estrogen receptor, and it is clinically evaluated for PET imaging to detect and stage breast cancer, ovarian cancer, and cancer of uterine endometrium and myometrium.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| 18F-Fluoroestradiol PET: Current Status and Potential Future Clinical Applications. | 2016 Aug |
|
| Improved Estrogen Receptor Assessment by PET Using the Novel Radiotracer (18)F-4FMFES in Estrogen Receptor-Positive Breast Cancer Patients: An Ongoing Phase II Clinical Trial. | 2018 Feb |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 07:24:11 GMT 2023
by
admin
on
Sat Dec 16 07:24:11 GMT 2023
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| Record UNII |
T32277KB09
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| Record Status |
Validated (UNII)
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V09IX11
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NCI_THESAURUS |
C2124
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C62541
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Fluoroestradiol F-18
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| Related Record | Type | Details | ||
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NON-LABELED -> LABELED | |||
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BINDER->LIGAND |
BINDING
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RADIOISOTOPE -> RADIOISOTOPE |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |
