Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C12H4Cl6 |
| Molecular Weight | 360.878 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
ClC1=CC(=CC(Cl)=C1Cl)C2=CC(Cl)=C(Cl)C(Cl)=C2
InChI
InChIKey=ZHLICBPIXDOFFG-UHFFFAOYSA-N
InChI=1S/C12H4Cl6/c13-7-1-5(2-8(14)11(7)17)6-3-9(15)12(18)10(16)4-6/h1-4H
| Molecular Formula | C12H4Cl6 |
| Molecular Weight | 360.878 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Relative potencies of PAHs and PCBs based on the response of human cells. | 1999 Mar |
|
| Serum alters the uptake and relative potencies of halogenated aromatic hydrocarbons in cell culture bioassays. | 2000 Feb |
|
| Application of the ethoxyresorufin-O-deethylase (EROD) assay to mixtures of halogenated aromatic compounds. | 2001 |
|
| Effects of PCBs on reactive oxygen species (ROS) production by the immune cells of Paracentrotus lividus (Echinodermata). | 2001 Aug |
|
| Disposition of polychlorinated dibenzo-p-dioxins, dibenzofurans, and non-ortho polychlorinated biphenyls in pregnant long evans rats and the transfer to offspring. | 2001 Jun 1 |
|
| Induction of cytochrome P450 1B1 in MDA-MB-231 human breast cancer cells by non-ortho-substituted polychlorinated biphenyls. | 2002 Dec |
|
| Effects of several dioxin-like compounds on estrogen metabolism in the malignant MCF-7 and nontumorigenic MCF-10A human mammary epithelial cell lines. | 2003 Aug 1 |
|
| A mixture of dioxins, furans, and non-ortho PCBs based upon consensus toxic equivalency factors produces dioxin-like reproductive effects. | 2003 Jul |
|
| Brominated dioxin-like compounds: in vitro assessment in comparison to classical dioxin-like compounds and other polyaromatic compounds. | 2003 Sep |
|
| Analysis of Ah receptor pathway activation by brominated flame retardants. | 2004 Jun |
|
| Evaluation of relative potencies of PCB126 and PCB169 for the immunotoxicities in ovalbumin (OVA)-immunized mice. | 2004 Nov 1 |
|
| Inhibition of human and rat CYP1A2 by TCDD and dioxin-like chemicals. | 2005 Apr |
|
| EROD induction and PCDD/F levels in fish liver from the Biobio River in Chile. | 2005 Aug |
|
| Apoptosis in bovine cumulus-oocyte complexes after exposure to polychlorinated biphenyl mixtures during in vitro maturation. | 2005 Dec |
|
| Induction of cytochrome P450 1A5 mRNA, protein and enzymatic activities by dioxin-like compounds, and congener-specific metabolism and sequestration in the liver of wild jungle crow (Corvus macrorhynchos) from Tokyo, Japan. | 2005 Dec |
|
| Coplanar PCB congeners increase uterine weight and frontal cortical dopamine in the developing rat: implications for developmental neurotoxicity. | 2005 Jul |
|
| PAH- and PCB-induced alterations of protein tyrosine kinase and cytokine gene transcription in harbor seal (Phoca vitulina) PBMC. | 2005 Jun |
|
| Effects of maternal exposure to 3,3',4,4',5-pentachlorobiphenyl (PCB126) or 3,3',4,4',5,5'-hexachlorobiphenyl (PCB169) on testicular steroidogenesis and spermatogenesis in male offspring rats. | 2005 Mar-Apr |
|
| Lineage-specific effects of polychlorinated biphenyls (PCB) on gene expression in the rabbit blastocyst. | 2005 May-Jun |
|
| Cytochrome P450 1A4 and 1A5 in common cormorant (Phalacrocorax carbo): evolutionary relationships and functional implications associated with dioxin and related compounds. | 2006 Aug |
|
| Mechanistic study of polychlorinated biphenyl 126-induced CYP11B1 and CYP11B2 up-regulation. | 2006 Mar |
|
| Comparison of hepatic and extra hepatic induction of cytochrome P4501A by graded doses of aryl hydrocarbon receptor agonists in Atlantic tomcod from two populations. | 2006 Mar 10 |
|
| Uncoupling of cytochrome P450 1A and stimulation of reactive oxygen species production by co-planar polychlorinated biphenyl congeners. | 2006 May 25 |
|
| The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds. | 2006 Oct |
|
| Evaluation of gas chromatographic isotope fractionation and process contamination by carbon in compound-specific radiocarbon analysis. | 2007 Mar 1 |
|
| Long-term effects of polychlorinated biphenyls and dioxins on pregnancy outcomes in women affected by the Yusho incident. | 2008 May |
|
| Association of organochlorine pesticides with peripheral neuropathy in patients with diabetes or impaired fasting glucose. | 2008 Nov |
|
| Reactive oxygen species from the uncoupling of human cytochrome P450 1B1 may contribute to the carcinogenicity of dioxin-like polychlorinated biphenyls. | 2008 Nov |
|
| Oxidative stress and apoptosis of Carassius auratus lymphocytes induced by nonplanar (PCB153) and coplanar (PCB169) polychlorinated biphenyl congeners in vitro. | 2009 |
|
| In vivo acute exposure to polychlorinated biphenyls: effects on free and total thyroxine in rats. | 2009 Sep-Oct |
|
| Polychlorinated biphenyls, lead, and mercury are associated with liver disease in American adults: NHANES 2003-2004. | 2010 Dec |
|
| Developing tools for risk assessment in protected species: Relative potencies inferred from competitive binding of halogenated aromatic hydrocarbons to aryl hydrocarbon receptors from beluga (Delphinapterus leucas) and mouse. | 2010 Nov 1 |
|
| In utero and lactational exposure to a complex mixture of polychlorinated biphenyls: toxicity in pups dependent on the Cyp1a2 and Ahr genotypes. | 2011 Jan |
|
| Aryl hydrocarbon receptor ligands of widely different toxic equivalency factors induce similar histone marks in target gene chromatin. | 2011 May |
|
| In utero and lactational exposure to PCBs in mice: adult offspring show altered learning and memory depending on Cyp1a2 and Ahr genotypes. | 2011 Sep |
|
| Consensus toxicity factors for polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls combining in silico models and extensive in vitro screening of AhR-mediated effects in human and rodent cells. | 2015 Apr 20 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 17:19:45 GMT 2023
by
admin
on
Fri Dec 15 17:19:45 GMT 2023
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| Record UNII |
T2P1WH546D
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| Record Status |
Validated (UNII)
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| Record Version |
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DTXSID2038314
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36231
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T2P1WH546D
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3948
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32774-16-6
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