LOMETRALINE HYDROCHLORIDE

Details

Stereochemistry	UNKNOWN
Molecular Formula	C13H18ClNO.ClH
Molecular Weight	276.202
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.COC1=CC=C(Cl)C2=C1CCCC2N(C)C

InChI

InChIKey=XYTNPORBXPAQMP-UHFFFAOYSA-N

InChI=1S/C13H18ClNO.ClH/c1-15(2)11-6-4-5-9-12(16-3)8-7-10(14)13(9)11;/h7-8,11H,4-6H2,1-3H3;1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C13H18ClNO
Molecular Weight	239.741
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4401233 | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 739, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ | https://www.ncbi.nlm.nih.gov/pubmed/25268963

Lometraline is a tranquillizer and anti-parkinsonian drug. It was developed as an antidepressant agent. Lometraline is a congener of popular antidepressant (+)-sertraline.

Approval Year

PubMed

Title	Date	PubMed
Evaluation of an aminotetraline, CP 14.368, as an antidepressant.	1972 Feb	4401233
[A case of migrainous infarction accompanying idiopathic thrombocytopenic purpura].	2002 Sep	12710087
[Sporadic hemiplegic migraine-like headache in a patient with systemic lupus erythematosus].	2010 May	20535984

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:25:26 GMT 2023` Edited by `admin` on `Fri Dec 15 15:25:26 GMT 2023`
Record UNII	T2OJ193WGR
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LOMETRALINE HYDROCHLORIDE

Official Name

English

CP-143681

Code

English

LOMETRALINE HYDROCHLORIDE [USAN]

Common Name

English

CP-14,368-1

Code

English

8-Chloro-1,2,3,4-tetrahydro-5-methoxy-N,N-dimethyl-1-naphthylamine hydrochloride

Systematic Name

English

CP-14368-1

Code

English

LOMETRALINE HCL

Common Name

English

1-NAPHTHALENAMINE, 8-CHLORO-1,2,3,4-TETRAHYDRO-5-METHOXY-N,N-DIMETHYL-, HYDROCHLORIDE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C94725