Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C27H30N7OS.K |
| Molecular Weight | 539.737 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[K+].CCCCC1=NC(C)=C(CC(=S)N(C)C)C(=O)N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NN=N[N-]4
InChI
InChIKey=OCKQGXSJNJCCDO-UHFFFAOYSA-N
InChI=1S/C27H30N7OS.K/c1-5-6-11-24-28-18(2)23(16-25(36)33(3)4)27(35)34(24)17-19-12-14-20(15-13-19)21-9-7-8-10-22(21)26-29-31-32-30-26;/h7-10,12-15H,5-6,11,16-17H2,1-4H3;/q-1;+1
| Molecular Formula | K |
| Molecular Weight | 39.0983 |
| Charge | 1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C27H31N7OS |
| Molecular Weight | 501.646 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionCurator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/23811571, http://www.boryung.co.kr/eng/product/mainProduct.do
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/23811571, http://www.boryung.co.kr/eng/product/mainProduct.do
Fimasartan is a angiotensin II receptor antagonist which was developed in Korea for the treatment of hypertension. The drug is available in different forms: Kanarb, Dukarb (in combination with Amlodipine), Tuvero (in combination with Rosuvastatin). Fimasartan was tested to be effective in Mexican and Russian population and now is being tested in the USA.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Pharmacokinetic interaction of fimasartan, a new angiotensin II receptor antagonist, with amlodipine in healthy volunteers. | 2011 Jun |
|
| Effect of age on the pharmacokinetics of fimasartan (BR-A-657). | 2011 Nov |
|
| Fimasartan, a novel angiotensin II receptor antagonist. | 2012 Jul |
|
| Pharmacological characterization of BR-A-657, a highly potent nonpeptide angiotensin II receptor antagonist. | 2013 |
|
| Safety and efficacy of fimasartan in patients with arterial hypertension (Safe-KanArb study): an open-label observational study. | 2013 Feb |
|
| Effect of renal function on the pharmacokinetics of fimasartan: a single-dose, open-label, Phase I study. | 2014 |
|
| The Efficacy of Fimasartan for Cardiovascular Events and Metabolic Syndrome (K-MetS Study): Rationale, Design and Participant Characteristics. | 2014 May |
|
| Cardioprotective effect of fimasartan, a new angiotensin receptor blocker, in a porcine model of acute myocardial infarction. | 2015 Jan |
Patents
Sample Use Guides
Fimasartan is taken as a single oral dose of 60-mg tablet or a single 30-mg intravenous (IV) infusion.
Route of Administration:
Other
Rabbit thoracic aorta cells were incubated with different concentrations of fimasartan ((0.1, 1, 10 nM). At those concentrations fimasartan caused nonparallel rightward shifts in the concentration–contractile response curve to Ang II with a significant reduction in the maximal contractile response to 96.6, 47 and 18%, respectively.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 10:50:37 UTC 2023
by
admin
on
Sat Dec 16 10:50:37 UTC 2023
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| Record UNII |
T2ICP7GBBN
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| Record Status |
Validated (UNII)
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| Record Version |
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100000168911
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71465067
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1402813-38-0
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admin on Sat Dec 16 10:50:37 UTC 2023 , Edited by admin on Sat Dec 16 10:50:37 UTC 2023
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NON-SPECIFIC STOICHIOMETRY |
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SOLVATE->ANHYDROUS | |||
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PARENT -> SALT/SOLVATE |
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