Exerenibart

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 19:04:02 GMT 2025` Edited by `admin` on `Wed Apr 02 19:04:02 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG4\|KAPPA
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	T2CP32988Q
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

Exerenibart

Official Name

English

REGN-7999

Preferred Name

English

REGN7999

Code

English

exerenibart [INN]

Common Name

English

Immunoglobulin G4 [232-proline], anti-(human/Macaca fascicularis/Mus musculus/Rattus norvegicus transmembrane serine proteinase 6) (human monoclonal REGN7999 ?4-chain), disulfide with human monoclonal REGN7999 ?-chain, dimer

Common Name

English

immunoglobulin G4-kappa, anti-[Homo sapiens TMPRSS6 (transmembrane serine protease 6, matriptase-2, MT2)], Homo sapiens monoclonal antibody; H-gamma4 heavy chain Homo sapiens (1-451) [VH (Homo sapiens IGHV3-23*04 (95.9%) -(IGHD) -IGHJ1*01 (90.9%) L123>T

Common Name

English

Code System Code Type Description

INN

13405

Created by admin on Wed Apr 02 19:04:02 GMT 2025 , Edited by admin on Wed Apr 02 19:04:02 GMT 2025

PRIMARY

CAS

2996101-49-4

Created by admin on Wed Apr 02 19:04:02 GMT 2025 , Edited by admin on Wed Apr 02 19:04:02 GMT 2025

PRIMARY

FDA UNII

T2CP32988Q

Created by admin on Wed Apr 02 19:04:02 GMT 2025 , Edited by admin on Wed Apr 02 19:04:02 GMT 2025

PRIMARY

From	To
1_22	1_96
2_22	2_96
2_138	4_214
2_151	2_207
2_265	2_325
1_138	3_214
2_371	2_429
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194
1_151	1_207
1_230	2_230
1_233	2_233
1_265	1_325
1_371	1_429

Glycosylation Link Type	Site
N	1_301
N	2_301

Related Record Type Details


					7OG8I08TRT

TRANSMEMBRANE PROTEASE SERINE 6

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					T2CP32988Q

Exerenibart

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS	E		PIDOLIC ACID	SZB83O1W42
AMINO ACID REMOVAL	[1_451] [2_451]	C-TERMINUS			LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL