Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C16H10FN3 |
| Molecular Weight | 262.2716 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[18F]C1=CC=C(C=N1)C2=CC=C3C(NC4=C3C=NC=C4)=C2
InChI
InChIKey=GETAAWDSFUCLBS-SJPDSGJFSA-N
InChI=1S/C16H10FN3/c17-16-4-2-11(8-19-16)10-1-3-12-13-9-18-6-5-14(13)20-15(12)7-10/h1-9,20H/i17-1
| Molecular Formula | C16H10FN3 |
| Molecular Weight | 262.2716 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Flortaucipir (18F-AV-1451, also known as 18F-T807) is a highly selective positron emission tomography (PET) imaging agent targeting paired helical filament (PHF)-tau in the brain. This tracer is studying for clinical assessment in patients with various tauopathies, including Alzheimer's disease, as well as in healthy subjects.
CNS Activity
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| [(18)F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease. | 2013 Nov |
|
| Synthesis and quality control of [(18) F]T807 for tau PET imaging. | 2016 Aug |
|
| Tau-PET Binding Distinguishes Patients With Early-stage Posterior Cortical Atrophy From Amnestic Alzheimer Disease Dementia. | 2017 Apr-Jun |
|
| Quantification of Tau Load Using [18F]AV1451 PET. | 2017 Dec |
|
| Region-Specific Association of Subjective Cognitive Decline With Tauopathy Independent of Global β-Amyloid Burden. | 2017 Dec 1 |
|
| Relationships between flortaucipir PET tau binding and amyloid burden, clinical diagnosis, age and cognition. | 2017 Mar 1 |
|
| 18 F-flortaucipir tau positron emission tomography distinguishes established progressive supranuclear palsy from controls and Parkinson disease: A multicenter study. | 2017 Oct |
|
| 18F-Flortaucipir PET/MRI Correlations in Nonamnestic and Amnestic Variants of Alzheimer Disease. | 2018 Feb |
Patents
Sample Use Guides
Flortaucipir PET images were acquired for 20 min, as four 5-min frames, beginning 80 min after injection of 370 MBq flortaucipir. On a separate day, subjects underwent a florbetapir PET scan for 10 min, as two 5-min frames, beginning 50 min after injection of 370 MBq florbetapir F18.
Route of Administration:
Parenteral
| Substance Class |
Chemical
Created
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Mon Oct 21 22:49:52 UTC 2019
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Mon Oct 21 22:49:52 UTC 2019
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1522051-90-6
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10203
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CHEMBL3546271
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