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Details

Stereochemistry ACHIRAL
Molecular Formula C16H10FN3
Molecular Weight 262.2716
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FLORTAUCIPIR F-18

SMILES

[18F]C1=NC=C(C=C1)C2=CC3=C(C=C2)C4=C(N3)C=CN=C4

InChI

InChIKey=GETAAWDSFUCLBS-SJPDSGJFSA-N
InChI=1S/C16H10FN3/c17-16-4-2-11(8-19-16)10-1-3-12-13-9-18-6-5-14(13)20-15(12)7-10/h1-9,20H/i17-1

HIDE SMILES / InChI
Molecular Formula C16H10FN3
Molecular Weight 262.2716
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Flortaucipir (18F-AV-1451, also known as 18F-T807) is a highly selective positron emission tomography (PET) imaging agent targeting paired helical filament (PHF)-tau in the brain. This tracer is studying for clinical assessment in patients with various tauopathies, including Alzheimer's disease, as well as in healthy subjects.

CNS Activity

Originator

Approval Year

2020
742
Targets

Targets

Primary TargetPharmacologyConditionPotency
Binding Agent
1064
 14.6 nM [Kd]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
Phase III
656
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
[(18)F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease.
2013 Nov
Synthesis and quality control of [(18) F]T807 for tau PET imaging.
2016 Aug
Tau-PET Binding Distinguishes Patients With Early-stage Posterior Cortical Atrophy From Amnestic Alzheimer Disease Dementia.
2017 Apr-Jun
Region-Specific Association of Subjective Cognitive Decline With Tauopathy Independent of Global β-Amyloid Burden.
2017 Dec 1
Tau PET imaging: present and future directions.
2017 Feb 20
Hierarchical Organization of Tau and Amyloid Deposits in the Cerebral Cortex.
2017 Jul 1
Relationships between flortaucipir PET tau binding and amyloid burden, clinical diagnosis, age and cognition.
2017 Mar 1
(18) F-flortaucipir tau positron emission tomography distinguishes established progressive supranuclear palsy from controls and Parkinson disease: A multicenter study.
2017 Oct
(18)F-Flortaucipir PET/MRI Correlations in Nonamnestic and Amnestic Variants of Alzheimer Disease.
2018 Feb
Patents

Patents

WO2017083198A1
1

Sample Use Guides

In Vivo Use Guide
Flortaucipir PET images were acquired for 20 min, as four 5-min frames, beginning 80 min after injection of 370 MBq flortaucipir. On a separate day, subjects underwent a florbetapir PET scan for 10 min, as two 5-min frames, beginning 50 min after injection of 370 MBq florbetapir F18.
Route of Administration: Parenteral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Sat Dec 16 09:53:51 UTC 2023
Edited
by admin
on Sat Dec 16 09:53:51 UTC 2023
Record UNII
T1JP1KYU9O
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FLORTAUCIPIR F-18
Common Name English
Flortaucipir (18F) [WHO-DD]
Common Name English
FLORTAUCIPIR F 18
USAN  
USAN  
Official Name English
LY3191748
Code English
7-(6-(F-18)FLUOROPYRIDIN-3-YL)-5H-PYRIDO(4,3-B)INDOLE
Common Name English
T807 F-18
Code English
FLORTAUCIPIR F 18 [USAN]
Common Name English
(F-18)T807
Code English
AV-1451 F-18
Code English
[18F]FLORTAUCIPIR
Common Name English
TAUVID
Brand Name English
18F-AV-1451
Code English
flortaucipir (¹⁸F) [INN]
Common Name English
T-807 F-18
Code English
FLORTAUCIPIR F18 [MI]
Common Name English
FLORTAUCIPIR F-18 [ORANGE BOOK]
Common Name English
FLORTAUCIPIR (18F)
INN   WHO-DD  
INN  
Official Name English
LY-3191748
Code English
Code System Code Type Description
PUBCHEM
70957463
Created by admin on Sat Dec 16 09:53:52 UTC 2023 , Edited by admin on Sat Dec 16 09:53:52 UTC 2023
PRIMARY
DRUG BANK
DB14914
Created by admin on Sat Dec 16 09:53:52 UTC 2023 , Edited by admin on Sat Dec 16 09:53:52 UTC 2023
PRIMARY
WIKIPEDIA
Flortaucipir (18F)
Created by admin on Sat Dec 16 09:53:52 UTC 2023 , Edited by admin on Sat Dec 16 09:53:52 UTC 2023
PRIMARY
MERCK INDEX
m12220
Created by admin on Sat Dec 16 09:53:52 UTC 2023 , Edited by admin on Sat Dec 16 09:53:52 UTC 2023
PRIMARY
USAN
CD-33
Created by admin on Sat Dec 16 09:53:52 UTC 2023 , Edited by admin on Sat Dec 16 09:53:52 UTC 2023
PRIMARY
CAS
1522051-90-6
Created by admin on Sat Dec 16 09:53:51 UTC 2023 , Edited by admin on Sat Dec 16 09:53:51 UTC 2023
PRIMARY
EPA CompTox
DTXSID001027893
Created by admin on Sat Dec 16 09:53:52 UTC 2023 , Edited by admin on Sat Dec 16 09:53:52 UTC 2023
PRIMARY
INN
10203
Created by admin on Sat Dec 16 09:53:52 UTC 2023 , Edited by admin on Sat Dec 16 09:53:52 UTC 2023
PRIMARY
SMS_ID
100000178384
Created by admin on Sat Dec 16 09:53:52 UTC 2023 , Edited by admin on Sat Dec 16 09:53:52 UTC 2023
PRIMARY
DAILYMED
T1JP1KYU9O
Created by admin on Sat Dec 16 09:53:52 UTC 2023 , Edited by admin on Sat Dec 16 09:53:52 UTC 2023
PRIMARY
ChEMBL
CHEMBL3546271
Created by admin on Sat Dec 16 09:53:52 UTC 2023 , Edited by admin on Sat Dec 16 09:53:52 UTC 2023
PRIMARY
FDA UNII
T1JP1KYU9O
Created by admin on Sat Dec 16 09:53:52 UTC 2023 , Edited by admin on Sat Dec 16 09:53:52 UTC 2023
PRIMARY
RXCUI
2372689
Created by admin on Sat Dec 16 09:53:52 UTC 2023 , Edited by admin on Sat Dec 16 09:53:52 UTC 2023
PRIMARY
NCI_THESAURUS
C171887
Created by admin on Sat Dec 16 09:53:52 UTC 2023 , Edited by admin on Sat Dec 16 09:53:52 UTC 2023
PRIMARY
Related Record Type Details
MICROTUBULE-ASSOCIATED PROTEIN TAU (PAIRED HELICAL FILAMENTS (PHF))
TARGET->RADIOLIGAND
Images aggregates
Related Record Type Details
Structure of FLORTAUCIPIR F-18
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