NEBIDRAZINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C9H8Cl2N6
Molecular Weight	271.106
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	2
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NN1C=NN\C1=N\N=C\C2=C(Cl)C=CC=C2Cl

InChI

InChIKey=KHCYGOIWSWLPNL-YIXHJXPBSA-N

InChI=1S/C9H8Cl2N6/c10-7-2-1-3-8(11)6(7)4-13-15-9-16-14-5-17(9)12/h1-5H,12H2,(H,15,16)/b13-4+

HIDE SMILES / InChI

Molecular Formula	C9H8Cl2N6
Molecular Weight	271.106
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4040381 | https://www.ncbi.nlm.nih.gov/pubmed/19710

Nebidrazine (FLA-136) is a selective agonist at central alpha-adrenoreceptors mediating changes in the turnover of noradrenaline. Nebidrazine is a sedative agent.

Approval Year

PubMed

Title	Date	PubMed
FLA 136: selective agonist at central alpha-adrenoreceptors mediating changes in the turnover of noradrenaline.	1977 Jul	19710
Selective stimulation of central alpha-autoreceptors following treatment with alpha-methyldopa and FLA 136.	1979 Apr	38408
Involvement of presynaptic alpha-adrenoceptors in the cardiovascular and sedative effects of FLA-136.	1979 Mar	221842
A comparison of the cardiovascular and sedative actions of the alpha-adrenoceptor agonists, FLA-136 and clonidine, in the rat.	1982 Jan	6122478
Norepinephrine turnover and voluntary consumption of ethanol in the rat.	1985 Mar-Apr	4040381

Sample Use Guides

In Vivo Use Guide

The effect of Nebidrazine (FLA-136) on voluntary ethanol intake was investigated in the laboratory rat. Doses of 1.5, 7.5, 15 and 25 mg/kg of FLA-136 were administered to animals chronically exposed to ethanol on a free choice basis. Administration of the highest dose of the drug brought about a 40% reduction in voluntary ethanol intake with no significant effect on total fluid consumption.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:11:51 GMT 2023` Edited by `admin` on `Fri Dec 15 16:11:51 GMT 2023`
Record UNII	SYD5G2AE8M
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NEBIDRAZINE

Official Name

English

nebidrazine [INN]

Common Name

English

2,6-DICHLOROBENZALDEHYDE (4-AMINO-4H-1,2,4-TRIAZOL-3-YL)HYDRAZONE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C270