Nifurfoline is an imidazolidine-2,4-dione belonging to the family of nitrofurans. The spectrum of activity of the molecule is wide. Nifurfolina acts in fact on Escherichia coli , Proteus , Klebsiella , Enterobacter , staphylococci and enterococci . The antibacterial mechanism of action consists of inhibition of the Krebs cycle in terms of the formation of acetyl coenzyme A, citric acid and oxalacetic acid. This triple inhibition leads to a drastic reduction in the production of energy necessary for the multiplication or survival of bacteria. The drug can induce resistance, but very slowly. Nifurfolina is indicated in the treatment of urinary tract infections, acute or chronic, sustained by sensitive germs, even secondary to instrumental investigations (for example bladder catheterization ). It is also indicated in cystitis, pyelitis, cystopielites, nephritis and pyelonephritis, urethritis and prostatitis.