2-AMINONAPHTHIAZOLE

N=C1NC2=C3C=CC=CC3=CC=C2S1

InChIKey=FECQXVPRUCCUIL-UHFFFAOYSA-N

InChI=1S/C11H8N2S/c12-11-13-10-8-4-2-1-3-7(8)5-6-9(10)14-11/h1-6H,(H2,12,13)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Potency
Intermediate conductance calcium-activated potassium channel protein 4 10 Target ID: CHEMBL4305 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18955585	Activator 1430	260.0 nM [EC50]
Small conductance calcium-activated potassium channel protein 1 5 Target ID: CHEMBL2369 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18955585	Activator 1430	2.9 µM [EC50]
Small conductance calcium-activated potassium channel protein 3 3 Target ID: CHEMBL3381 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18955585	Activator 1430	2.9 µM [EC50]

PubMed

Title	Date	PubMed
Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure.	2009 Feb	18955585

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:46:09 GMT 2023` Edited by `admin` on `Fri Dec 15 17:46:09 GMT 2023`
Record UNII	SW12CAS9T7
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

2-AMINONAPHTHIAZOLE

Systematic Name

English

.ALPHA.-NAPHTHOTHIAZOLE, 1-AMINO-

Systematic Name

English

NSC-6278

Code

English

NAPHTHO(1,2-D)THIAZOLE, 2-AMINO-

Systematic Name

English

SKA-31

Code

English

2-AMINONAPHTHO(1,2-D)THIAZOLE

Systematic Name

English

Code System Code Type Description

PUBCHEM

94880