2-AMINONAPHTHIAZOLE

N=C1NC2=C3C=CC=CC3=CC=C2S1

InChIKey=FECQXVPRUCCUIL-UHFFFAOYSA-N

InChI=1S/C11H8N2S/c12-11-13-10-8-4-2-1-3-7(8)5-6-9(10)14-11/h1-6H,(H2,12,13)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Potency
Intermediate conductance calcium-activated potassium channel protein 4 13 Target ID: CHEMBL4305 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18955585	Activator 1447	260.0 nM [EC50]
Small conductance calcium-activated potassium channel protein 1 5 Target ID: CHEMBL2369 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18955585	Activator 1447	2.9 µM [EC50]
Small conductance calcium-activated potassium channel protein 3 3 Target ID: CHEMBL3381 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18955585	Activator 1447	2.9 µM [EC50]

PubMed

Title	Date	PubMed
SKA-31, an activator of Ca2+-activated K+ channels, improves cardiovascular function in aging.	2020-01	31707036
Modulation of Cardiovascular Function in Primary Hypertension in Rat by SKA-31, an Activator of KCa2.x and KCa3.1 Channels.	2019-08-23	31450834
SKA-31, an activator of endothelial Ca2+-activated K+ channels evokes robust vasodilation in rat mesenteric arteries.	2018-07-15	29753043
Inhibition of Myogenic Tone in Rat Cremaster and Cerebral Arteries by SKA-31, an Activator of Endothelial KCa2.3 and KCa3.1 Channels.	2015-07	25815673
Genetic deficit of SK3 and IK1 channels disrupts the endothelium-derived hyperpolarizing factor vasodilator pathway and causes hypertension.	2009-05-05	19380617
Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure.	2009-02	18955585

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:51:59 GMT 2025` Edited by `admin` on `Mon Mar 31 18:51:59 GMT 2025`
Record UNII	SW12CAS9T7
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

NSC-6278

Preferred Name

English

2-AMINONAPHTHIAZOLE

Systematic Name

English

.ALPHA.-NAPHTHOTHIAZOLE, 1-AMINO-

Systematic Name

English

NAPHTHO(1,2-D)THIAZOLE, 2-AMINO-

Systematic Name

English

SKA-31

Code

English

2-AMINONAPHTHO(1,2-D)THIAZOLE

Systematic Name

English

Code System Code Type Description

PUBCHEM

94880