FITUSIRAN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Sat Dec 16 11:09:36 GMT 2023` Edited by `admin` on `Sat Dec 16 11:09:36 GMT 2023`
Nucleic Acid Subtype
Sequence Type	OLIGONUCLEOTIDE
Record UNII	SV9W47ZLE1
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

FITUSIRAN

Official Name

English

ALN-AT3SC

Code

English

RNA, ((2'-DEOXY-2'-FLUORO)G-SP-GM-SP-(2'-DEOXY-2'-FLUORO)U-UM-(2'-DEOXY-2'-FLUORO)A-AM-(2'-DEOXY-2'-FLUORO)C-AM-(2'-DEOXY-2'-FLUORO)C-(2'-DEOXY-2'-FLUORO)C-(2'-DEOXY-2'-FLUORO)A-UM-(2'-DEOXY-2'-FLUORO)U-UM-(2'-DEOXY-2'-FLUORO)A-CM-(2'-DEOXY-2'-FLUORO)U-U

Systematic Name

English

SMALL INTERFERING RNA (SIRNA) INHIBITING ANTITHROMBIN LIVER PRODUCTION: DUPLEX OF ((2S,4R)-1-(1-((2-ACETAMIDO-2-DEOXY-.BETA.-D-GALACTOPYRANOSYL)OXY)-16,16-BIS((3-((3-(5-((2-ACETAMIDO-2-DEOXY-.BETA.-D-GALACTOPYRANOSYL)OXY)PENTANAMIDO)PROPYL)AMINO)-3-OXOPR

Systematic Name

English

Fitusiran [WHO-DD]

Common Name

English

ALN-57213

Code

English

FITUSIRAN [USAN]

Common Name

English

fitusiran [INN]

Common Name

English

Code System Code Type Description

INN

10177

Created by admin on Sat Dec 16 11:09:36 GMT 2023 , Edited by admin on Sat Dec 16 11:09:36 GMT 2023

PRIMARY

NCI_THESAURUS

C169984

Created by admin on Sat Dec 16 11:09:36 GMT 2023 , Edited by admin on Sat Dec 16 11:09:36 GMT 2023

PRIMARY

DRUG BANK

DB15002

Created by admin on Sat Dec 16 11:09:36 GMT 2023 , Edited by admin on Sat Dec 16 11:09:36 GMT 2023

PRIMARY

CAS

1499251-18-1

Created by admin on Sat Dec 16 11:09:36 GMT 2023 , Edited by admin on Sat Dec 16 11:09:36 GMT 2023

PRIMARY

USAN

FG-138

Created by admin on Sat Dec 16 11:09:36 GMT 2023 , Edited by admin on Sat Dec 16 11:09:36 GMT 2023

PRIMARY

FDA UNII

SV9W47ZLE1

Created by admin on Sat Dec 16 11:09:36 GMT 2023 , Edited by admin on Sat Dec 16 11:09:36 GMT 2023

PRIMARY

Sugar	Site Range	Site Count
2'-Fluoro-Ribose	1_2;1_4;1_6;1_8;1_10;1_14;1_16;1_18;1_20;2_1;2_3;2_5;2_7;2_9-2_11;2_13;2_15;2_17;2_19;2_21-2_22	22 / 45
2'-O-Methyl-Ribose	1_1;1_3;1_5;1_7;1_9;1_11-1_13;1_15;1_17;1_19;1_21-1_23;2_2;2_4;2_6;2_8;2_12;2_14;2_16;2_18;2_20	23 / 45

Linkage	Site Range	Site Count
Phosporothioate	1_2-1_3;1_22-1_23;2_2-2_3	6 / 43
Phosphate	1_4-1_21;2_4-2_22	37 / 43

Related Record Type Details


					A2PQ8BS44A

FITUSIRAN SODIUM

SALT/SOLVATE -> PARENT

Amount:

Related Record Type Details


					SV9W47ZLE1

FITUSIRAN

ACTIVE MOIETY

Agent Modifications

Modification Process	Modification Role	Modification Type	Amount	Fragment Name	Fragment ID

Physical Modifications

Modification Role	Parameter Name	Amount

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOTIDE SUBSTITUTION	[2_22]	3'-TERMINUS	X		CEMDISIRAN, TERMINAL SUGAR MODIFICATION-	CQQ59545BV

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL