U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Nucleic Acid
Created
by admin
on Thu Jul 06 16:44:59 UTC 2023
Edited
by admin
on Thu Jul 06 16:44:59 UTC 2023
Nucleic Acid Subtype
Sequence Type OLIGONUCLEOTIDE
Record UNII
SV9W47ZLE1
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FITUSIRAN
WHO-DD  
INN   USAN  
Official Name English
ALN-AT3SC
Code English
RNA, ((2'-DEOXY-2'-FLUORO)G-SP-GM-SP-(2'-DEOXY-2'-FLUORO)U-UM-(2'-DEOXY-2'-FLUORO)A-AM-(2'-DEOXY-2'-FLUORO)C-AM-(2'-DEOXY-2'-FLUORO)C-(2'-DEOXY-2'-FLUORO)C-(2'-DEOXY-2'-FLUORO)A-UM-(2'-DEOXY-2'-FLUORO)U-UM-(2'-DEOXY-2'-FLUORO)A-CM-(2'-DEOXY-2'-FLUORO)U-U
Systematic Name English
SMALL INTERFERING RNA (SIRNA) INHIBITING ANTITHROMBIN LIVER PRODUCTION: DUPLEX OF ((2S,4R)-1-(1-((2-ACETAMIDO-2-DEOXY-.BETA.-D-GALACTOPYRANOSYL)OXY)-16,16-BIS((3-((3-(5-((2-ACETAMIDO-2-DEOXY-.BETA.-D-GALACTOPYRANOSYL)OXY)PENTANAMIDO)PROPYL)AMINO)-3-OXOPR
Systematic Name English
Fitusiran [WHO-DD]
Common Name English
ALN-57213
Code English
FITUSIRAN [USAN]
Common Name English
fitusiran [INN]
Common Name English
Code System Code Type Description
INN
10177
Created by admin on Thu Jul 06 16:44:59 UTC 2023 , Edited by admin on Thu Jul 06 16:44:59 UTC 2023
PRIMARY
NCI_THESAURUS
C169984
Created by admin on Thu Jul 06 16:44:59 UTC 2023 , Edited by admin on Thu Jul 06 16:44:59 UTC 2023
PRIMARY
DRUG BANK
DB15002
Created by admin on Thu Jul 06 16:44:59 UTC 2023 , Edited by admin on Thu Jul 06 16:44:59 UTC 2023
PRIMARY
CAS
1499251-18-1
Created by admin on Thu Jul 06 16:44:59 UTC 2023 , Edited by admin on Thu Jul 06 16:44:59 UTC 2023
PRIMARY
USAN
FG-138
Created by admin on Thu Jul 06 16:44:59 UTC 2023 , Edited by admin on Thu Jul 06 16:44:59 UTC 2023
PRIMARY
FDA UNII
SV9W47ZLE1
Created by admin on Thu Jul 06 16:44:59 UTC 2023 , Edited by admin on Thu Jul 06 16:44:59 UTC 2023
PRIMARY
Sugar Site Range Site Count
2'-Fluoro-Ribose 1_2;1_4;1_6;1_8;1_10;1_14;1_16;1_18;1_20;2_1;2_3;2_5;2_7;2_9-2_11;2_13;2_15;2_17;2_19;2_21-2_22 22 / 45
2'-O-Methyl-Ribose 1_1;1_3;1_5;1_7;1_9;1_11-1_13;1_15;1_17;1_19;1_21-1_23;2_2;2_4;2_6;2_8;2_12;2_14;2_16;2_18;2_20 23 / 45
Linkage Site Range Site Count
Phosporothioate 1_2-1_3;1_22-1_23;2_2-2_3 6 / 43
Phosphate 1_4-1_21;2_4-2_22 37 / 43
Related Record Type Details
SALT/SOLVATE -> PARENT
Related Record Type Details
ACTIVE MOIETY

Agent Modifications

Modification Process Modification Role Modification Type Amount Fragment Name Fragment ID

Physical Modifications

Modification Role Parameter Name Amount

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
NUCLEOTIDE SUBSTITUTION [2_22] 3'-TERMINUS X CEMDISIRAN, TERMINAL SUGAR MODIFICATION- CQQ59545BV
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL