Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C17H17N3 |
| Molecular Weight | 263.337 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C1C[C@@H](NC2=NC3=C(N2)C=CC=C3)C4=C(C1)C=CC=C4
InChI
InChIKey=XZIZUQSOFMLIIR-CQSZACIVSA-N
InChI=1S/C17H17N3/c1-2-8-13-12(6-1)7-5-11-14(13)18-17-19-15-9-3-4-10-16(15)20-17/h1-4,6,8-10,14H,5,7,11H2,(H2,18,19,20)/t14-/m1/s1
| Molecular Formula | C17H17N3 |
| Molecular Weight | 263.337 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: Q9UGI6 Gene ID: 3782.0 Gene Symbol: KCNN3 Target Organism: Homo sapiens (Human) |
0.73 µM [Kd] | ||
Target ID: Q9H2S1 Gene ID: 3781.0 Gene Symbol: KCNN2 Target Organism: Homo sapiens (Human) |
0.6 µM [Kd] | ||
Target ID: Q92952 Gene ID: 3780.0 Gene Symbol: KCNN1 Target Organism: Homo sapiens (Human) |
0.42 µM [Kd] | ||
Target ID: CHEMBL3780 |
0.077 µM [Kd] | ||
Target ID: CHEMBL2369 |
0.42 µM [Kd] | ||
Target ID: CHEMBL4469 |
0.6 µM [Kd] |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Arrhythmia development during inhibition of small-conductance calcium-activated potassium channels in acute myocardial infarction in a porcine model. | 2019-10-01 |
|
| Modulation of Mg2+ influx and cytoplasmic free Mg2+ concentration in rat ventricular myocytes. | 2019-01 |
|
| Prostaglandin E2 increases migration and proliferation of human glioblastoma cells by activating transient receptor potential melastatin 7 channels. | 2018-12 |
|
| TRPM6 is Essential for Magnesium Uptake and Epithelial Cell Function in the Colon. | 2018-06-18 |
|
| Endogenous and Agonist-induced Opening of Mitochondrial Big Versus Small Ca2+-sensitive K+ Channels on Cardiac Cell and Mitochondrial Protection. | 2017-11 |
|
| Store-operated Ca2+ entry is not required for fertilization-induced Ca2+ signaling in mouse eggs. | 2017-07 |
|
| Identity and function of a cardiac mitochondrial small conductance Ca2+-activated K+ channel splice variant. | 2017-06 |
|
| The TRPM7 channel kinase regulates store-operated calcium entry. | 2017-05-15 |
|
| In vivo analysis of cerebellar Purkinje cell activity in SCA2 transgenic mouse model. | 2016-06-01 |
|
| Mibefradil represents a new class of benzimidazole TRPM7 channel agonists. | 2016-04 |
|
| Antiarrhythmic Effect of Either Negative Modulation or Blockade of Small Conductance Ca2+-activated K+ Channels on Ventricular Fibrillation in Guinea Pig Langendorff-perfused Heart. | 2015-09 |
|
| Pharmacologic inhibition of small-conductance calcium-activated potassium (SK) channels by NS8593 reveals atrial antiarrhythmic potential in horses. | 2015-04 |
|
| Physiological pathway of magnesium influx in rat ventricular myocytes. | 2014-11-04 |
|
| TRPM7 regulates proliferation and polarisation of macrophages. | 2014-11-01 |
|
| Expression and contributions of TRPM7 and KCa2.3/SK3 channels to the increased migration and invasion of microglia in anti-inflammatory activation states. | 2014 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 22:00:14 GMT 2025
by
admin
on
Mon Mar 31 22:00:14 GMT 2025
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| Record UNII |
STF2BZ33XF
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| Record Status |
Validated (UNII)
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| Record Version |
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