MYELIN BASIC PROTEIN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 00:58:06 GMT 2025` Edited by `admin` on `Wed Apr 02 00:58:06 GMT 2025`
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	SSA5AV2ZFK
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MYELIN BASIC PROTEIN

Common Name

English

MBP

Preferred Name

English

MYELIN MEMBRANE ENCEPHALITOGENIC PROTEIN

Common Name

English

MYELIN A1 PROTEIN

Common Name

English

Classification Tree Code System Code

LOINC

56661-2

Created by admin on Wed Apr 02 00:58:06 GMT 2025 , Edited by admin on Wed Apr 02 00:58:06 GMT 2025

LOINC

26940-7

Created by admin on Wed Apr 02 00:58:06 GMT 2025 , Edited by admin on Wed Apr 02 00:58:06 GMT 2025

LOINC

2638-5

Created by admin on Wed Apr 02 00:58:06 GMT 2025 , Edited by admin on Wed Apr 02 00:58:06 GMT 2025

Code System Code Type Description

FDA UNII

SSA5AV2ZFK

Created by admin on Wed Apr 02 00:58:06 GMT 2025 , Edited by admin on Wed Apr 02 00:58:06 GMT 2025

PRIMARY

UNIPROT

P02686

Created by admin on Wed Apr 02 00:58:06 GMT 2025 , Edited by admin on Wed Apr 02 00:58:06 GMT 2025

PRIMARY

Glycosylation Link Type	Site
N	1_55

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Amount:


					NUF3QN2O79

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Amount:


					26188K0CWH

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Comments:

Developed for the treatment of Multiple Sclerosis (MS). Did not meet the primary endpoint of delaying disease progression, as measured by the Expanded Disability Status Scale (EDSS), during the two-year MAESTRO-01 Phase III trial in patients with secondary progressive multiple sclerosis (SPMS).

Amount:


					EM69RKN4VC

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Amount:


					6VN101530Y

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Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_141] [1_146] [1_153] [1_174] [1_190] [1_210] [1_249] [1_295]	SITE_SPECIFIC			DEXFOSFOSERINE	VI4F0K069V
AMINO_ACID_SUBSTITUTION	[1_237] [1_281]	SITE_SPECIFIC			Glutamic Acid	3KX376GY7L
AMINO_ACID_SUBSTITUTION	[1_177] [1_183]	SITE_SPECIFIC			TILARGININE	27JT06E6GR
AMINO_ACID_SUBSTITUTION	[1_151] [1_154] [1_169] [1_214] [1_229] [1_232]	SITE_SPECIFIC			THREONINE PHOSPHATE	3L4WX7B1EI
AMINO_ACID_SUBSTITUTION	[1_148] [1_203]	SITE_SPECIFIC			TYROSINE O-PHOSPHATE	2R86C98KDX

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL