3-METHYLTHYMINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C6H8N2O2
Molecular Weight	140.1399
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1C(=O)NC=C(C)C1=O

InChI

InChIKey=IIDONYMEGWHGRU-UHFFFAOYSA-N

InChI=1S/C6H8N2O2/c1-4-3-7-6(10)8(2)5(4)9/h3H,1-2H3,(H,7,10)

HIDE SMILES / InChI

Molecular Formula	C6H8N2O2
Molecular Weight	140.1399
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Formation and repair of tobacco carcinogen-derived bulky DNA adducts.	2010-12-20	21234336
The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice.	2010-11-16	21103374
Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase.	2010-11-11	21068844
Mice lacking Alkbh1 display sex-ratio distortion and unilateral eye defects.	2010-11-03	21072209
Repair of DNA Alkylation Damage by the Escherichia coli Adaptive Response Protein AlkB as Studied by ESI-TOF Mass Spectrometry.	2010-10-27	21048928
Nucleotide sequence and genome organization of Dweet mottle virus and its relationship to members of the family Betaflexiviridae.	2010-09	20644968
Ab initio investigation of the methylation and hydration effects on the electronic spectra of uracil and thymine.	2010-05-21	20445899
Risk of type 2 diabetes and obesity is differentially associated with variation in FTO in whites and African-Americans in the ARIC study.	2010-05-20	20502638
From monogenic to polygenic obesity: recent advances.	2010-03	20127379
Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats.	2010-01-19	20098739
Structural and mutational analysis of Escherichia coli AlkB provides insight into substrate specificity and DNA damage searching.	2010-01-13	20084272
Prevalence of loss-of-function FTO mutations in lean and obese individuals.	2010-01	19833892
Uracil and thymine reactivity in the gas phase: the S(N)2 reaction and implications for electron delocalization in leaving groups.	2009-12-30	19928991
Hypothalamic FTO is associated with the regulation of energy intake not feeding reward.	2009-10-27	19860904
A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene.	2009-08	19680540
A non-heme iron-mediated chemical demethylation in DNA and RNA.	2009-04-21	19852088
Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO.	2008-10-15	18775698
'Fat mass and obesity associated' gene (FTO): no significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents.	2008-09-17	18799002
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.	2007-11-30	17991826
Demethylation of 3-methylthymine in DNA by bacterial and human DNA dioxygenases.	2004-09-24	15269201
Acyclic nucleoside analogues as novel inhibitors of human mitochondrial thymidine kinase.	2002-09-12	12213066

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:02:50 GMT 2025` Edited by `admin` on `Mon Mar 31 19:02:50 GMT 2025`
Record UNII	SS2K4WB6YL
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

3-METHYLTHYMINE

Systematic Name

English

3,5-DIMETHYLURACIL

Preferred Name

English

NSC-750725

Code

English

Code System Code Type Description

NSC

750725