ISOPROMETHAZINE HYDROCHLORIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C17H20N2S.ClH
Molecular Weight	320.88
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of ISOPROMETHAZINE HYDROCHLORIDE

Structure Search

SMILES

Cl.CC(CN(C)C)N1C2=CC=CC=C2SC3=C1C=CC=C3

InChI

InChIKey=RISCHQYUHLQSBU-UHFFFAOYSA-N

InChI=1S/C17H20N2S.ClH/c1-13(12-18(2)3)19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19;/h4-11,13H,12H2,1-3H3;1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C17H20N2S
Molecular Weight	284.419
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Approval Year

PubMed

Title	Date	PubMed
The acute and sub-chronic effects of levocetirizine, cetirizine, loratadine, promethazine and placebo on cognitive function, psychomotor performance, and weal and flare.	2001	11922397
[Work time distribution in night shift: are clinics facing a adjustment boom?].	2001 Jul	12025123
[The activity of enzymes and free radical oxidation in acute and chronic fetal hypoxia in general anesthesia during cesarean section].	2002	12577498
Ketoconazole potentiates terfenadine-induced apoptosis in human Hep G2 cells through inhibition of cytochrome p450 3A4 activity.	2002	12244568
[Suicidal attempts with old (currently unused) drug].	2002	12184019
Antiallergic anti-inflammatory effects of H1-antihistamines in humans.	2002	12113215
Antihistamine antinociception is mediated by Gi-protein activation.	2002	11927163
Investigation of the effect of tablet surface area/volume on drug release from hydroxypropylmethylcellulose controlled-release matrix tablets.	2002 Apr	12056539
Immunoassay screening of lysergic acid diethylamide (LSD) and its confirmation by HPLC and fluorescence detection following LSD ImmunElute extraction.	2002 Apr	11991536
Study of the stability of promethazine enantiomers by liquid chromatography using a vancomycin-bonded chiral stationary phase.	2002 Apr 25	12013245
A systematic approach to the management of postoperative nausea and vomiting.	2002 Dec	12476402
Inhibitory effects of H1-antihistamines on CYP2D6- and CYP2C9-mediated drug metabolic reactions in human liver microsomes.	2002 Feb	11936702
An evaluation of the effects of high-dose fexofenadine on the central nervous system: a double-blind, placebo-controlled study in healthy volunteers.	2002 Jan	12002730
[A case of fluvoxamine overdose].	2002 Jan	11977737
Investigation of interaction of promethazine with cyclodextrins.	2002 Jan-Feb	12026112
Bradykinin is involved in hyperalgesia induced by Bothrops jararaca venom.	2002 Jul	12076660
Recovery, enrichment and selectivity in liquid-phase microextraction comparison with conventional liquid-liquid extraction.	2002 Jul 19	12187984
Project USAP 2000--use of sedative agents by pediatric dentists: a 15-year follow-up survey.	2002 Jul-Aug	12212869
Fibromyositis after intramuscular pentazocine abuse.	2002 Jul-Sep	12432208
In vitro reversal of chloroquine resistance in Plasmodium falciparum with dihydroethanoanthracene derivatives.	2002 Jun	12224571
Indirect spectrophotometric determination of propranolol hydrochloride and piroxicam in pure and pharmaceutical formulations.	2002 Jun	12083553
Central effects of cinnarizine: restricted use in aircrew.	2002 Jun	12056673
Next generation antihistamines: therapeutic rationale, accomplishments and advances.	2002 Jun	12036424
Putative identification of functional interactions between DNA intercalating agents and topoisomerase II using the V79 in vitro micronucleus assay.	2002 Jun 19	12052500
[Validation of the HPLC method in the determination of dioxopromethazine and phenylephrine in eye drops].	2002 Mar	11928283
Interaction of protonated anticancer thiazines with water-insoluble phospholipids and antineoplastic agents.	2002 Mar-Apr	12014679
Liquid-phase microextraction of protein-bound drugs under non-equilibrium conditions.	2002 May	12081037
Anxiolytic premedication reduces preoperative anxiety and pain during oocyte retrieval. A randomized double-blinded placebo-controlled trial.	2002 May	11980744
Simultaneous determination of promethazine, chlorpromazine, and perphenazine by multivariate calibration methods and derivative spectrophotometry.	2002 May-Jun	12083247
Effect of some psychotropic drugs on luminol-dependent chemiluminescence induced by O2-, *OH, HOCl.	2002 Nov-Dec	12562096
Antiemetic use in pediatric gastroenteritis: a national survey of emergency physicians, pediatricians, and pediatric emergency physicians.	2002 Nov-Dec	12462313
Metabolism of zaleplon by human liver: evidence for involvement of aldehyde oxidase.	2002 Oct	12419014
Preparation, characterization and taste-masking properties of polyvinylacetal diethylaminoacetate microspheres containing trimebutine.	2002 Oct	12396292
Acute allergic reaction following contact with a spider.	2002 Oct	12368120
TREC-Rio trial: a randomised controlled trial for rapid tranquillisation for agitated patients in emergency psychiatric rooms [ISRCTN44153243].	2002 Oct 16	12383353
[Landau-Kleffner and autistic regression: the importance of differential diagnosis].	2002 Sep	12364957
A case of homicide by lethal injection with lidocaine.	2002 Sep	12353561
Enantioseparation of phenothiazines in cyclodextrin-modified micellar electrokinetic chromatography.	2002 Sep 20	12350123
Interaction between various resistance modifiers and apoptosis inducer 12H-benzo[alpha]phenothiazine.	2002 Sep-Oct	12530005
The effects of acute doses of fexofenadine, promethazine, and placebo on cognitive and psychomotor function in healthy Japanese volunteers.	2003 Apr	12722962
Classic histamine H1 receptor antagonists: a critical review of their metabolic and pharmacokinetic fate from a bird's eye view.	2003 Apr	12678691
Histamine H1-receptor antagonists, promethazine and homochlorcyclizine, increase the steady-state plasma concentrations of haloperidol and reduced haloperidol.	2003 Apr	12657913
Inactivation of cholinesterase induced by chlorpromazine cation radicals.	2003 Feb	12747580
Effect of phenothiazines on protein kinase C- and calcium-dependent activation of peritoneal macrophages.	2003 Feb	12661983
Reye's syndrome: down but not out.	2003 Jan	12602712
Interaction of carbamazepine and promethazine in rabbits.	2003 Jan	12583009
In vitro human plasma leucine(5)-enkephalin degradation is inhibited by a select number of drugs with the phenothiazine molecule in their chemical structure.	2003 Jan	12444298
Phenothiazine radicals inactivate Trypanosoma cruzi dihydrolipoamide dehydrogenase: enzyme protection by radical scavengers.	2003 Mar	12688423
Clinical practice. Vestibular neuritis.	2003 Mar 13	12637613
Hyperalgesia induced by Asp49 and Lys49 phospholipases A2 from Bothrops asper snake venom: pharmacological mediation and molecular determinants.	2003 May	12727271

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 08:33:47 GMT 2023` Edited by `admin` on `Sat Dec 16 08:33:47 GMT 2023`
Record UNII	SNR56923ZU
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ISOPROMETHAZINE HYDROCHLORIDE

Common Name

English

ISOPROMETHAZINE HYDROCHLORIDE [MI]

Common Name

English

PROMETHAZINE RELATED COMPOUND B [USP-RS]

Common Name

English

DIPRAZIN

Brand Name

English

10H-PHENOTHIAZINE-10-ETHANAMINE, N,N,.BETA.-TRIMETHYL-, MONOHYDROCHLORIDE

Systematic Name

English

10H-PHENOTHIAZINE-10-ETHANAMINE, N,N,.BETA.-TRIMETHYL-, HYDROCHLORIDE (1:1)

Systematic Name

English

PHENOTHIAZINE, 10-(2-(DIMETHYLAMINO)-1-METHYLETHYL)-, MONOHYDROCHLORIDE

Systematic Name

English

Isopromethazine hydrochloride [WHO-DD]

Common Name

English

Code System Code Type Description

RS_ITEM_NUM

1570029