Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C8H11NO.ClH |
| Molecular Weight | 173.64 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CCC1=NC(C)=CC=C1O
InChI
InChIKey=KZUIXWYHQJZUOK-UHFFFAOYSA-N
InChI=1S/C8H11NO.ClH/c1-3-7-8(10)5-4-6(2)9-7;/h4-5,10H,3H2,1-2H3;1H
| Molecular Formula | C8H11NO |
| Molecular Weight | 137.179 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Emoxypine (ethylmethylhydroxypyridine) succinate (MEXIDOL®) is a 3-hydroxypyridine derivative which is quite similar in structure to Vitamin B6 (pyridoxine). The most important components of the mechanism of action of Mexidol® are its antioxidant and membranotropic effects, the ability to modulate functioning of receptors and membrane-bound enzymes, restore a neurotransmitter balance. Due to its mechanism of action Mexidol® has a wide range of pharmacological effects, realized on at least two levels – neuronal and vascular. It has antihypoxic, anti-ischemic, neuroprotective, nootropic, vegetotrophic, anti-stress, anxiolytic, anticonvulsant, anti-alcohol, cardioprotective, anti-atherogenic, geroprotective and other actions. Under the action of Mexidol®, it is observed an improvement in cerebral circulation and microcirculation. Emoxypine is distributed in Russia but it is widely unknown in other regions.
Originator
Curator's Comment: In early 1980s, in State Institution Research Institute of Pharmacology of RAMS, by L.D. Smirnov and V.I. Kuzmin, 2-ethyl-6-methyl-3-hydroxypyridine succinate was synthesized, and under supervision of Academician of RAMS A.V. Valdman, its pharmacological effects were found, the mechanism of action was studied, preclinical studies on toxicology and pharmacokinetics were carried out, the Mexidol® trademark was identified, the drug was registered in the USSR Ministry of Healthcare, the first clinical trials and introduction of the preparation into medical practice were carried out.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| [Experience with complex treatment for childhood amblyopia]. | 2008-03-06 |
|
| [Pharmacological correction of neuronal damage in sensomotor zone of frontal cortex under conditions of experimental cerebral blood flow pathology]. | 2008-03-06 |
|
| [The regulatory effect of mexidol on the hemoglobin level under acute stress conditions]. | 2007-12-14 |
|
| [Acute radiation sickness in experiment. Efficacy of mexidol]. | 2007-10-13 |
|
| [Effect of mexidol on hemopoietic system in conditions of an emotional stress after exposure to ionizing radiation]. | 2007-06-19 |
|
| Efficacy of neuroprotectors in patients with tension headaches. | 2007-06 |
|
| [Combined action of mexidol and non-narcotic analgesics on pain thresholds and emotional stress behavior in animals]. | 2007-05-26 |
|
| [The effect of rubomycin, mexidol and emoxypine on some metabolic indexes and the proccess of spontaneous metastasis under conditions of experimental neoplasia]. | 2007-04-04 |
|
| Lymphotropic effect of dimephosphon, mexidol, and ketorolac is realized via activation of the lymphangion and stimulation of lymph formation. | 2007-04 |
|
| [The efficacy of oxynicotinic acid a nd its derivatives in respect of functional activity of hepatocytes during acute toxic hepatopathy]. | 2007-02-16 |
|
| [The effectiveness of ascorbic acid and emoxipin in treatment of infiltrative pulmonary tuberculosis]. | 2007 |
|
| [The efficacy of complex therapy of ventricular arrhythmias with emoxipin and preductal in combination with antiarrhythmic agents]. | 2007 |
|
| [Influence of gel Metrogil Denta and curative toothpaste Mexidol Dent activ on indices of parodontal status and lipid peroxidation in patients with chronic generalized catarrhal gingivitis]. | 2007 |
|
| [The influence of 3-oxypyridine antioxidants on depression in patients with diabetes mellitus]. | 2007 |
|
| Effect of mexidol and nitroglycerine on iron-sulfur centers, cytochrome P-450, and nitric oxide formation in liver tissue of experimental animals. | 2006-10 |
|
| [Antistressor and analgesic effects of mexidol, diazepam, paracetamol, and their combinations]. | 2006-09-26 |
|
| [Antioxidant activity of inhibitors of free radical reactions in the dressing materials for wound healing]. | 2006-06-03 |
|
| [The experimental study of peculiarities and mechanism of neuroprotective action of mexidol in hemorrhagic stroke]. | 2006 |
|
| [Efficacy of the use of antioxidant preparation mexidol in comprehensive treatment of inflammatory diseases of parodontium]. | 2006 |
|
| [The use of mexidol in urgent treatment of drug addiction]. | 2006 |
|
| [Mexidol in combined treatment of acute pancreatitis]. | 2006 |
|
| [Clinical and immunological assessment of efficacy of mexidol in the treatment of lumbosacral radiculopathy]. | 2006 |
|
| [Lipid reducing and antioxidant action of mexicor in patients with diabetes mellitus type 2]. | 2006 |
|
| [Antioxidants in complex treatment of Parkinson's disease]. | 2006 |
|
| [Neurometabolic therapy of diabetic neuropathy]. | 2006 |
|
| [Complex therapy of acute and exacerbated chronic nonspecific parotitis including mexidol and non-coherent infrared therapy]. | 2006 |
|
| [The use of mexidol in psychiatric practice]. | 2006 |
|
| [Neureprotective drugs efficiency in patients with chronic tension headaches]. | 2006 |
|
| [Antihypoxant activity and mechanisms of action of some natural and synthetic compounds]. | 2005-11-10 |
|
| [Estimating the potential of antioxidant therapy for patients with Parkinson's disease diagnosis]. | 2005-11-10 |
|
| [A comparative study of the development of drug differentiation between mexidol and phenazepam]. | 2005-11-10 |
|
| Lymphotropic effect of mexidol in reactive fever. | 2005-10 |
|
| Activity of nitric oxide synthase and concentration of nitric oxide end metabolites in the gingiva under experimental pathological conditions. | 2005-10 |
|
| [Study of antiradical activity of new compounds by chemiluminescence]. | 2005-08-18 |
|
| [Metabolic effects of mexidole during cardiosurgical operations using extracorporeal circulation]. | 2005-08-04 |
|
| [Mexidol corrects model post-reanimation changes in cerebral lipid metabolism]. | 2005-07-29 |
|
| [Biotransformation of mexidol in inbred BALB/C and C57BL/6 mice]. | 2005-06-07 |
|
| [Efficiency of mexidol during perinatal encephalopathy in early age children]. | 2005-06 |
|
| [Antinecrotic and antiischemic effect of mexidol and trental in ischemia of the skin graft]. | 2005-05 |
|
| [Mexidol in treatment of children with generalized epilepsy and febrile seizures]. | 2005-05 |
|
| The effects of Mexidol on the acquisition of food-related conditioned reflexes and synaptic ultrastructure in field CA1 of the rat hippocampus after single acoustic stimuli with ultrasonic components. | 2005-05 |
|
| Antihypoxic and antinecrotic effect of mexidol in skin ischemia. | 2005-02 |
|
| [Protective effect of activators of biological oxidation in nitrite intoxication in rats]. | 2005 |
|
| [The treatment of patients with toxic encephalopathy caused by using surrogate psychoactive manganese-containing compounds]. | 2005 |
|
| [Effects of mexidol on the antioxidative status of patients suffering from coronary heart disease with dislipidemia]. | 2005 |
|
| [Effects of emoxipine, reamberine and mexidol on neuropathic symptoms and a systolic function of the left ventricular myocardium in patients with diabetes mellitus and diabetic foot syndrome]. | 2005 |
|
| [Methodological bases of early psychosocial rehabilitation of poststroke patients in neurological hospital]. | 2005 |
|
| [Effect of mexicor on oxidative stress in acute myocardial infarction]. | 2005 |
|
| [Results of application of synthetic antioxidants in treatment of patients with destructive pancreatitis]. | 2005 |
|
| [Efficacy of emoxypine in combined therapy for elderly patients with postinfarct cardiosclerosis and heart failure]. | 2004 |
Patents
| Substance Class |
Chemical
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SN1FWZ77AE
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